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Opinion|Videos|December 4, 2025

Future Directions for ctDNA-Based Testing in MIBC

Author(s)Joshua J. Meeks, MD, PhD, BS, Alan Tan, MD

The experts conclude this program by discussing future biomarker-guided approaches in bladder cancer treatment.

Episodes in this series

Two experts are featured in this series.

EP. 1 Challenges in MIBC Management and Opportunities for ctDNA-based Testing

EP. 2 Exploratory Analysis of ctDNA in MIBC from CheckMate 274

EP. 2 Exploratory Analysis of ctDNA in MIBC from CheckMate 274

Two experts are featured in this series.

EP. 3 Evaluating ctDNA Biomarkers in MIBC from SunRISe-4

Two experts are featured in this series.

EP. 4 Opportunities for Guiding Neoadjuvant Treatment Decisions with ctDNA in MIBC

Two experts are featured in this series.

EP. 5 Assessing ctDNA-Guided Therapy in MIBC in IMvigor011

Two experts are featured in this series.

EP. 6 Implications for ctDNA-Guided Adjuvant Decision-Making in MIBC

Two experts are featured in this series.

EP. 7 Future Directions for ctDNA-Based Testing in MIBC

The experts conclude this program by discussing future biomarker-guided approaches in bladder cancer treatment. They propose designing studies that use molecular markers to guide treatment intensification or de-escalation. The conversation explores potential research directions, emphasizing the need for personalized, adaptive treatment strategies. Dr. Meeks and Dr. Tan express optimism about the future of molecular medicine, highlighting how advanced testing might improve patient outcomes. Their dialogue underscores the transformative potential of precision medicine in understanding and treating muscle-invasive bladder cancer. They critically examine current limitations in treatment selection, discussing how molecular markers could provide more refined, patient-specific approaches. The conversation reveals the growing potential of biomarker-guided strategies to revolutionize clinical decision-making and improve patient care.

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