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Opinion|Videos|November 25, 2025

Implications for ctDNA-Guided Adjuvant Decision-Making in MIBC

Author(s)Joshua J. Meeks, MD, PhD, BS, Alan Tan, MD

The panelists investigate emerging molecular testing technologies, focusing on whole genome sequencing and advanced profiling techniques.

Episodes in this series

Two experts are featured in this series.

EP. 1 Challenges in MIBC Management and Opportunities for ctDNA-based Testing

EP. 2 Exploratory Analysis of ctDNA in MIBC from CheckMate 274

EP. 2 Exploratory Analysis of ctDNA in MIBC from CheckMate 274

Two experts are featured in this series.

EP. 3 Evaluating ctDNA Biomarkers in MIBC from SunRISe-4

Two experts are featured in this series.

EP. 4 Opportunities for Guiding Neoadjuvant Treatment Decisions with ctDNA in MIBC

Two experts are featured in this series.

EP. 5 Assessing ctDNA-Guided Therapy in MIBC in IMvigor011

Two experts are featured in this series.

EP. 6 Implications for ctDNA-Guided Adjuvant Decision-Making in MIBC

The panelists investigate emerging molecular testing technologies, focusing on whole genome sequencing and advanced profiling techniques. They discuss current limitations in sensitivity and potential improvements in detecting minimal residual disease. The conversation explores how more comprehensive molecular analysis could enhance precision medicine approaches. They reflect on the rapid technological advancements and their potential to transform bladder cancer management. The experts emphasize the importance of continued research and development in molecular diagnostics. Their dialogue critically examines the challenges of current testing platforms, discussing potential strategies to improve sensitivity and specificity. They explore how emerging technologies might provide more comprehensive insights into disease biology, highlighting the potential for more personalized, targeted treatment strategies.

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Stay up to date on recent advances in the multidisciplinary approach to cancer.

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Final Thoughts and Future Innovations

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