scout
Opinion|Videos|November 18, 2025

Evaluating ctDNA Biomarkers in MIBC from SunRISe-4

Drs. Meeks and Tan explore the SunRISe-4 trial, highlighting its innovative combination of intravesical therapy and immunotherapy.

Drs. Meeks and Tan explore the SunRISe-4 trial, highlighting its innovative combination of intravesical therapy and immunotherapy. They analyze the trial's unique approach of incorporating both circulating tumor DNA (ctDNA) and urinary tumor DNA (utDNA) testing. The discussion centers on how these molecular testing strategies could transform bladder preservation approaches. They examine the potential for personalized treatment decisions based on molecular markers, discussing the trial's implications for future research and clinical practice. The conversation reveals the growing importance of molecular profiling in understanding muscle-invasive bladder cancer (MIBC). Experts critically assess the trial's methodology, exploring how integrated molecular testing might provide more comprehensive disease insights. Their discussion highlights the potential of advanced diagnostic approaches to guide more precise, individualized treatment strategies.

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.


Latest CME