Opinion|Videos|January 31, 2025
Assessing Treatment Options for ALK+ NSCLC
This video segment provides an in-depth discussion on the first-line use of lorlatinib for ALK-positive metastatic NSCLC, including clinical evidence from the phase 3 CROWN trial, the broader therapeutic landscape and alternative strategies, real-world insights on lorlatinib's performance, and key considerations for selecting among ALK inhibitors based on patient-specific factors.
Advertisement
Episodes in this series
Video content above is prompted by the following:
- Can you summarize the clinical evidence supporting lorlatinib use in the first-line treatment of ALK+ metastatic NSCLC?
- Could you highlight the primary efficacy outcomes from the phase 3 CROWN trial?
- How would you describe the current therapeutic landscape metastatic ALK+ NSCLC?
- What alternative treatment strategies could have been considered for this patient?
- Based on your clinical experience, how has lorlatinib performed in real-world practice?
- What advantages and challenges have you encountered when incorporating lorlatinib into your treatment protocols?
- How do you approach the selection process among the various available ALK inhibitors?
- What key factors influence your decision?
- In which specific patient subgroups would you lean towards using alectinib, lorlatinib, or brigatinib (the NCCN preferred treatments)?
Advertisement
Related to this article
Pembrolizumab plus SBRT produced more toxicity vs SBRT alone among patients with early-stage non–small cell lung cancer in the phase 3 KEYNOTE-867 trial.
An end-of-phase 2 meeting with the FDA supports a phase 3 development program for silevertinib in patients with locally advanced or metastatic NSCLC.
The FDA issued a Not Approvable Letter due to uncertainty around the degree of clinical benefit with Optune Mya for patients with NSCLC and brain metastases.
In pooled phase 1/2 data, the PD-1/VEGF bispecific antibody cesalatamig produced a 33% objective response rate in PD-(L)1–resistant/refractory NSCLC.
Findings may provide reassurance to patients with early-stage disease that surgery may help improve survival rates.
Advertisement
Advertisement
Trending on CancerNetwork
1
FDA Approves Perioperative Durvalumab/Enfortumab Vedotin in MIBC
2
Subsequent Therapy May Have Narrowed the Overall Survival Gap in LITESPARK-011
3
Managing Emergencies During Outpatient Bispecific Step-Up Dosing
4
ACS Updates Prostate Cancer Screening Guideline With Risk-Based PSA Intervals
5