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Opinion|Videos|January 31, 2025

Assessing Treatment Options for ALK+ NSCLC

Author(s)Todd Bauer, MD, Sandip Patel, MD, Jonathan Riess, MD, MS

This video segment provides an in-depth discussion on the first-line use of lorlatinib for ALK-positive metastatic NSCLC, including clinical evidence from the phase 3 CROWN trial, the broader therapeutic landscape and alternative strategies, real-world insights on lorlatinib's performance, and key considerations for selecting among ALK inhibitors based on patient-specific factors.

Episodes in this series

6 experts are featured in this series.

EP. 1 Sarah’s Journey With ALK+ Metastatic NSCLC

6 experts are featured in this series.

EP. 2 The Role of Molecular Testing in Treatment Decisions for NSCLC

6 experts are featured in this series.

EP. 3 The Benefits of Lorlatinib for ALK+ NSCLC: CROWN Update

6 experts are featured in this series.

EP. 4 Assessing Treatment Options for ALK+ NSCLC

6 experts are featured in this series.

EP. 5 Treatment Sequencing Decisions in ALK+ NSCLC

6 experts are featured in this series.

EP. 6 Overview of Emerging ALK+ NSCLC Treatments

6 experts are featured in this series.

EP. 7 Eleanor’s Journey With KRAS+ Metastatic NSCLC

6 experts are featured in this series.

EP. 8 Overview of the Efficacy Data of Adagrasib in the Treatment of KRAS+ NSCLC

6 experts are featured in this series.

EP. 9 KRAS G12 Inhibitor Treatment Options

6 experts are featured in this series.

EP. 10 Is There a Role for KRAS Inhibitors in the First-Line Treatment of NSCLC?

6 experts are featured in this series.

EP. 11 KRAS+ NSCLC: Treatment Management Strategies

Findings from the phase 3 CROWN trial evaluating lorlatinib in ALK-positive non–small cell lung cancer revealed a sustained PFS benefit with the agent.

EP. 12 Integrating Lorlatinib Into First-Line ALK-Positive NSCLC Treatment

Video content above is prompted by the following:

Can you summarize the clinical evidence supporting lorlatinib use in the first-line treatment of ALK+ metastatic NSCLC?
Could you highlight the primary efficacy outcomes from the phase 3 CROWN trial?
How would you describe the current therapeutic landscape metastatic ALK+ NSCLC?
What alternative treatment strategies could have been considered for this patient?
Based on your clinical experience, how has lorlatinib performed in real-world practice?
What advantages and challenges have you encountered when incorporating lorlatinib into your treatment protocols?
How do you approach the selection process among the various available ALK inhibitors?
What key factors influence your decision?
In which specific patient subgroups would you lean towards using alectinib, lorlatinib, or brigatinib (the NCCN preferred treatments)?

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