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Opinion|Videos|February 21, 2025

KRAS G12 Inhibitor Treatment Options

Author(s)Todd Bauer, MD, Sandip Patel, MD, Jonathan Riess, MD, MS

This video segment examines strategies for managing adverse events associated with adagrasib, comparing its safety profile to other RAS GTPase inhibitors like sotorasib, and discusses key differences, benefits, and risks that may influence treatment selection or consideration of clinical trials.

Episodes in this series

6 experts are featured in this series.

EP. 1 Sarah’s Journey With ALK+ Metastatic NSCLC

6 experts are featured in this series.

EP. 2 The Role of Molecular Testing in Treatment Decisions for NSCLC

6 experts are featured in this series.

EP. 3 The Benefits of Lorlatinib for ALK+ NSCLC: CROWN Update

6 experts are featured in this series.

EP. 4 Assessing Treatment Options for ALK+ NSCLC

6 experts are featured in this series.

EP. 5 Treatment Sequencing Decisions in ALK+ NSCLC

6 experts are featured in this series.

EP. 6 Overview of Emerging ALK+ NSCLC Treatments

6 experts are featured in this series.

EP. 7 Eleanor’s Journey With KRAS+ Metastatic NSCLC

6 experts are featured in this series.

EP. 8 Overview of the Efficacy Data of Adagrasib in the Treatment of KRAS+ NSCLC

6 experts are featured in this series.

EP. 9 KRAS G12 Inhibitor Treatment Options

6 experts are featured in this series.

EP. 10 Is There a Role for KRAS Inhibitors in the First-Line Treatment of NSCLC?

6 experts are featured in this series.

EP. 11 KRAS+ NSCLC: Treatment Management Strategies

Findings from the phase 3 CROWN trial evaluating lorlatinib in ALK-positive non–small cell lung cancer revealed a sustained PFS benefit with the agent.

EP. 12 Integrating Lorlatinib Into First-Line ALK-Positive NSCLC Treatment

Video content above is prompted by the following:

What are some strategies you might consider when treating AEs seen with adagrasib? Which AEs are of greatest concern?
- How do the AEs reported in clinical trial for adagrasib compare with other inhibitors of the RAS GTPase family, like sotorasib and others currently under investigation?
What are some differences between adagrasib and sotorisib? What are some potential risks or benefits that may lead you to choose one of these over the other?
- When might you consider a clinical trial?

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