
Opinion|Videos|February 7, 2025
Treatment Sequencing Decisions in ALK+ NSCLC
This video segment examines therapeutic strategies for managing disease progression on lorlatinib in ALK-positive metastatic NSCLC, including decision-making considerations and scenarios where switching to lorlatinib from another ALK inhibitor may be beneficial.
Advertisement
Episodes in this series

Video content above is prompted by the following:
- If this patient were to experience disease progression on lorlatinib, what would be your next therapeutic approach and why?
- What considerations would guide your decision-making process?
- If this patient had started on a different ALK inhibitor, when/why might you consider a switch to lorlatinib?
Advertisement
Related to this article

Pembrolizumab plus SBRT produced more toxicity vs SBRT alone among patients with early-stage non–small cell lung cancer in the phase 3 KEYNOTE-867 trial.

An end-of-phase 2 meeting with the FDA supports a phase 3 development program for silevertinib in patients with locally advanced or metastatic NSCLC.

The FDA issued a Not Approvable Letter due to uncertainty around the degree of clinical benefit with Optune Mya for patients with NSCLC and brain metastases.

In pooled phase 1/2 data, the PD-1/VEGF bispecific antibody cesalatamig produced a 33% objective response rate in PD-(L)1–resistant/refractory NSCLC.
Advertisement
Advertisement
Trending on CancerNetwork
1
Anthracycline Chemo May Accelerate Biological Aging in Breast Cancer Survivors
2
Contextualizing MRD Negativity and PFS Across Treatment Regimens in Relapsed/Refractory Multiple Myeloma
3
CELMoDs With CAR T-Cell Therapy and Bispecific Antibodies in Multiple Myeloma
4
What Sustained MRD Negativity Can Settle About Stopping Myeloma Maintenance
5


