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Opinion|Videos|February 7, 2025

Treatment Sequencing Decisions in ALK+ NSCLC

Author(s)Todd Bauer, MD, Sandip Patel, MD, Jonathan Riess, MD, MS

This video segment examines therapeutic strategies for managing disease progression on lorlatinib in ALK-positive metastatic NSCLC, including decision-making considerations and scenarios where switching to lorlatinib from another ALK inhibitor may be beneficial.

Episodes in this series

6 experts are featured in this series.

EP. 1 Sarah’s Journey With ALK+ Metastatic NSCLC

6 experts are featured in this series.

EP. 2 The Role of Molecular Testing in Treatment Decisions for NSCLC

6 experts are featured in this series.

EP. 3 The Benefits of Lorlatinib for ALK+ NSCLC: CROWN Update

6 experts are featured in this series.

EP. 4 Assessing Treatment Options for ALK+ NSCLC

6 experts are featured in this series.

EP. 5 Treatment Sequencing Decisions in ALK+ NSCLC

6 experts are featured in this series.

EP. 6 Overview of Emerging ALK+ NSCLC Treatments

6 experts are featured in this series.

EP. 7 Eleanor’s Journey With KRAS+ Metastatic NSCLC

6 experts are featured in this series.

EP. 8 Overview of the Efficacy Data of Adagrasib in the Treatment of KRAS+ NSCLC

6 experts are featured in this series.

EP. 9 KRAS G12 Inhibitor Treatment Options

6 experts are featured in this series.

EP. 10 Is There a Role for KRAS Inhibitors in the First-Line Treatment of NSCLC?

6 experts are featured in this series.

EP. 11 KRAS+ NSCLC: Treatment Management Strategies

Findings from the phase 3 CROWN trial evaluating lorlatinib in ALK-positive non–small cell lung cancer revealed a sustained PFS benefit with the agent.

EP. 12 Integrating Lorlatinib Into First-Line ALK-Positive NSCLC Treatment

Video content above is prompted by the following:

If this patient were to experience disease progression on lorlatinib, what would be your next therapeutic approach and why?
- What considerations would guide your decision-making process?
If this patient had started on a different ALK inhibitor, when/why might you consider a switch to lorlatinib?

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