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Opinion|Videos|February 21, 2025

Balancing Treatment Intensity, Quality of Life, and Biomarker-Driven Approaches in Advanced GI Cancers

Author(s)David H. Ilson, MD, PhD, Sunnie Kim, MD, Raji Shameem, MD

Panelists discuss how balancing treatment intensity with quality of life remains a critical challenge in advanced gastric cancers (GCs) and how implementing biomarker-driven approaches such as PD-L1 combined positive score (CPS) testing faces practical hurdles in clinical settings. Key considerations include optimizing patient outcomes while managing adverse effects and addressing barriers such as testing accessibility, result turnaround time, and standardization of biomarker interpretation.

Episodes in this series

3 experts in this video

EP. 1 Treatment Landscape and Unmet Needs in Advanced Gastric Cancers

3 experts in this video

EP. 2 CheckMate649 5-Year Follow-Up, Study Design, and Efficacy Results

3 experts in this video

EP. 3 Evaluating Long-Term Outcomes and Personalized Treatment Strategies in Advanced Gastrointestinal Cancers

3 experts in this video

EP. 4 Assessing the Long-Term Safety and Efficacy of Nivolumab Plus Chemotherapy for Broader Clinical Adoption in Advanced GI Cancers

3 experts in this video

EP. 5 Balancing Treatment Intensity, Quality of Life, and Biomarker-Driven Approaches in Advanced GI Cancers

3 experts in this video

EP. 6 Advancing First-Line Treatment Strategies in Gastric and Esophageal Cancers

3 experts in this video

EP. 7 Key Takeaways and Future in Advanced Gastric Cancer Treatment

EP. 8 Updated Nivolumab Data Solidify Use in Advanced Gastric/GEJ/Esophageal Cancers

EP. 8 Updated Nivolumab Data Solidify Use in Advanced Gastric/GEJ/Esophageal Cancers

How might these findings shape discussions about the balance between treatment intensity and maintaining patients’ quality of life in advanced GC/gastroesophageal junction cancer/esophageal adenocarcinoma?
What barriers might exist in applying biomarker-driven approaches, such as PD-L1 CPS, in real-world clinical settings, and how can they be addressed?

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GI Tumor Board—Applying Recent Advances in Biomarker Testing and Treatment in Metastatic Colorectal Cancer

GI Tumor Board—Applying Recent Advances in Biomarker Testing and Treatment in Metastatic Colorectal Cancer

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$Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma$

Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma

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Breaking Down the Rationale for Targeting TROP2 in TNBC

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Cross-Disease Integration of Immunotherapy Innovations

Cross-Disease Integration of Immunotherapy Innovations

Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

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Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

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Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

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