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Opinion|Videos|February 7, 2025

CheckMate649 5-Year Follow-Up, Study Design, and Efficacy Results

Author(s)David H. Ilson, MD, PhD, Sunnie Kim, MD, Raji Shameem, MD

Panelists discuss how the CheckMate649 study was a randomized trial that compared nivolumab plus FOLFOX (leucovorin, fluorouracil, oxaliplatin) chemotherapy with chemotherapy alone for treating advanced gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma. The study results found that nivolumab plus chemotherapy improved overall survival and progression-free survival compared with chemotherapy alone.

Episodes in this series

3 experts in this video

EP. 1 Treatment Landscape and Unmet Needs in Advanced Gastric Cancers

3 experts in this video

EP. 2 CheckMate649 5-Year Follow-Up, Study Design, and Efficacy Results

3 experts in this video

EP. 3 Evaluating Long-Term Outcomes and Personalized Treatment Strategies in Advanced Gastrointestinal Cancers

3 experts in this video

EP. 4 Assessing the Long-Term Safety and Efficacy of Nivolumab Plus Chemotherapy for Broader Clinical Adoption in Advanced GI Cancers

3 experts in this video

EP. 5 Balancing Treatment Intensity, Quality of Life, and Biomarker-Driven Approaches in Advanced GI Cancers

3 experts in this video

EP. 6 Advancing First-Line Treatment Strategies in Gastric and Esophageal Cancers

3 experts in this video

EP. 7 Key Takeaways and Future in Advanced Gastric Cancer Treatment

EP. 8 Updated Nivolumab Data Solidify Use in Advanced Gastric/GEJ/Esophageal Cancers

EP. 8 Updated Nivolumab Data Solidify Use in Advanced Gastric/GEJ/Esophageal Cancers

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