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Opinion|Videos|February 14, 2025

Evaluating Long-Term Outcomes and Personalized Treatment Strategies in Advanced Gastrointestinal Cancers

Author(s)David H. Ilson, MD, PhD, Sunnie Kim, MD, Raji Shameem, MD

Panelists discuss how the long-term follow-up data from CheckMate649 are crucial for understanding the durability of nivolumab plus chemotherapy’s benefit in first-line advanced gastric cancers (GCs)/gastroesophageal junction cancers (GEJCs). The survival outcomes help validate this regimen’s position as a standard of care, particularly for patients with PD-L1 combined positive score (CPS) ≥ 5. Although the magnitude of benefit varies by PD-L1 expression, both overall survival (OS) and progression-free survival (PFS) data inform personalized treatment decisions, with stronger evidence supporting immunotherapy use in higher PD-L1–expressing tumors while maintaining use across most patient subgroups.

Episodes in this series

3 experts in this video

EP. 1 Treatment Landscape and Unmet Needs in Advanced Gastric Cancers

3 experts in this video

EP. 2 CheckMate649 5-Year Follow-Up, Study Design, and Efficacy Results

3 experts in this video

EP. 3 Evaluating Long-Term Outcomes and Personalized Treatment Strategies in Advanced Gastrointestinal Cancers

3 experts in this video

EP. 4 Assessing the Long-Term Safety and Efficacy of Nivolumab Plus Chemotherapy for Broader Clinical Adoption in Advanced GI Cancers

3 experts in this video

EP. 5 Balancing Treatment Intensity, Quality of Life, and Biomarker-Driven Approaches in Advanced GI Cancers

3 experts in this video

EP. 6 Advancing First-Line Treatment Strategies in Gastric and Esophageal Cancers

3 experts in this video

EP. 7 Key Takeaways and Future in Advanced Gastric Cancer Treatment

EP. 8 Updated Nivolumab Data Solidify Use in Advanced Gastric/GEJ/Esophageal Cancers

EP. 8 Updated Nivolumab Data Solidify Use in Advanced Gastric/GEJ/Esophageal Cancers

Please comment on the significance of a 5-year update for CheckMate649.
How might this affect your current clinical practice?
How do the OS and PFS benefits at 5 years reinforce or challenge nivolumab plus chemotherapy as the standard first-line treatment for this patient population?
How might the OS benefit in subgroups, particularly those defined by PD-L1 CPS thresholds, guide personalized treatment strategies for advanced GC/GEJC/esophageal adenocarcinoma?
How might these results influence treatment decisions for patients with low vs high PD-L1 CPSs?

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