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Opinion|Videos|October 11, 2024

Biomarkers and Clinical Features Influencing GPRC5D Bispecific Initiation

Author(s)Salman Fazal, MD , Yvonne Efebera, MD , Sumit Madan, MD

Panelists discuss how specific biomarkers, such as GPRC5D expression levels, and clinical features, influence their decision to initiate GPRC5D bispecific therapies in multiple myeloma patients.

Episodes in this series

4 KOLs are featured in this series.

EP. 1 GPRC5D-Targeted Therapies in Relapsed Multiple Myeloma

4 KOLs are featured in this series.

EP. 2 Real-World Efficacy of GPRC5D Bispecifics vs Clinical Trials

4 KOLs are featured in this series.

EP. 3 Patient Selection Factors for GPRC5D-Targeted Therapies

4 KOLs are featured in this series.

EP. 4 Patient Subgroup Outcomes with GPRC5D Bispecifics

4 KOLs are featured in this series.

EP. 5 Biomarkers and Clinical Features Influencing GPRC5D Bispecific Initiation

4 KOLs are featured in this series.

EP. 6 Integration of GPRC5D-Targeted Therapies in RRMM Treatment

4 KOLs are featured in this series.

EP. 7 Prevalent Safety Concerns in Community Settings

4 KOLs are featured in this series.

EP. 8 Challenging Adverse Events with GPRC5D-Targeted Therapies

4 KOLs are featured in this series.

EP. 9 Long-Term Monitoring Protocols for Bispecific Therapy Complications

4 KOLs are featured in this series.

EP. 10 Proactive Steps for Mitigating GPRC5D Therapy Adverse Events

4 KOLs are featured in this series.

EP. 11 Logistical Barriers in Implementing GPRC5D-Targeted Therapies

4 KOLs are featured in this series.

EP. 12 Healthcare Resource Utilization Impact of GPRC5D-Targeted Therapies

4 KOLs are featured in this series.

EP. 13 Resources Needed for Enhanced Bispecific Implementation

4 KOLs are featured in this series.

EP. 14 Areas for Improvement in Real-World GPRC5D-Targeted Therapy Application

4 KOLs are featured in this series.

EP. 15 Future Impact of GPRC5D-Targeted Therapies on RRMM Treatment

4 KOLs are featured in this series.

EP. 16 Unmet Needs and Future Directions for GPRC5D Bispecific Therapy

Are there specific biomarkers or clinical features that influence your decision to initiate GPRC5D bispecific therapies?

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

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Being able to treat patients with cevostamab who have multiple myeloma after 1 to 3 prior lines of therapy vs 4 lines may allow for better outcomes.

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$The median OS among patients with triple-class–exposed relapsed/refractory multiple myeloma with or without EMD was 12.6 months vs 36.4 months.$

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$The 6- and 12-month PFS rates were 76.4% and 68.2%, respectively, in patients with relapsed/refractory multiple myeloma who discontinued treatment with teclistamab early.$

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Current FDA expectations may allow patients to return to their community physicians at 2 weeks after administration of anitocabtagene autoleucel.

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