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Opinion|Videos|October 18, 2024

Challenging Adverse Events with GPRC5D-Targeted Therapies

Author(s)Salman Fazal, MD , Yvonne Efebera, MD , Sumit Madan, MD

Panelists discuss how cytokine release syndrome and neurological toxicities have been the most challenging adverse events to manage with GPRC5D-targeted therapies, requiring proactive monitoring and intervention strategies, while noting that these side effects are generally similar to those seen with other bispecifics.

Episodes in this series

4 KOLs are featured in this series.

EP. 1 GPRC5D-Targeted Therapies in Relapsed Multiple Myeloma

4 KOLs are featured in this series.

EP. 2 Real-World Efficacy of GPRC5D Bispecifics vs Clinical Trials

4 KOLs are featured in this series.

EP. 3 Patient Selection Factors for GPRC5D-Targeted Therapies

4 KOLs are featured in this series.

EP. 4 Patient Subgroup Outcomes with GPRC5D Bispecifics

4 KOLs are featured in this series.

EP. 5 Biomarkers and Clinical Features Influencing GPRC5D Bispecific Initiation

4 KOLs are featured in this series.

EP. 6 Integration of GPRC5D-Targeted Therapies in RRMM Treatment

4 KOLs are featured in this series.

EP. 7 Prevalent Safety Concerns in Community Settings

4 KOLs are featured in this series.

EP. 8 Challenging Adverse Events with GPRC5D-Targeted Therapies

4 KOLs are featured in this series.

EP. 9 Long-Term Monitoring Protocols for Bispecific Therapy Complications

4 KOLs are featured in this series.

EP. 10 Proactive Steps for Mitigating GPRC5D Therapy Adverse Events

4 KOLs are featured in this series.

EP. 11 Logistical Barriers in Implementing GPRC5D-Targeted Therapies

4 KOLs are featured in this series.

EP. 12 Healthcare Resource Utilization Impact of GPRC5D-Targeted Therapies

4 KOLs are featured in this series.

EP. 13 Resources Needed for Enhanced Bispecific Implementation

4 KOLs are featured in this series.

EP. 14 Areas for Improvement in Real-World GPRC5D-Targeted Therapy Application

4 KOLs are featured in this series.

EP. 15 Future Impact of GPRC5D-Targeted Therapies on RRMM Treatment

4 KOLs are featured in this series.

EP. 16 Unmet Needs and Future Directions for GPRC5D Bispecific Therapy

What adverse events have been most challenging to manage with GPRC5D-targeted therapies?
How are these being managed?
Do the AEs differ from other bispecifics?
In what ways could the availability of GPRC5D-targeted therapies impact the broader therapeutic landscape for RRMM in community practices?

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