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Opinion|Videos|February 4, 2025

Bispecifics in R/R MM: Key Data and Clinical Implications From ASH 2024 and Ongoing Trials

Author(s)Luciano Costa, MD, PhD, Bhagirathbhai Dholaria, MD, Carl Ola Landgren, MD, PhD

Panelists discuss how bispecific antibodies are reshaping the therapeutic approach in relapsed/refractory multiple myeloma (R/R MM), covering their mechanism of action, currently approved agents, and potential advantages. They explore how these therapies have transformed clinical decision-making, including optimal lines of therapy, patient selection, and best practices for integrating bispecifics into clinical practice.

Episodes in this series

EP. 1 Highlights from ASH 2024: Optimizing Frontline Therapy in Transplant-Eligible MM

EP. 1 Highlights from ASH 2024: Optimizing Frontline Therapy in Transplant-Eligible MM

EP. 2 Tailoring Induction Therapy in Newly Diagnosed Transplant-Eligible MM: Key Considerations

EP. 2 Tailoring Induction Therapy in Newly Diagnosed Transplant-Eligible MM: Key Considerations

EP. 3 AURIGA Trial Highlights: Daratumumab + Lenalidomide Maintenance in Newly Diagnosed MM

EP. 3 AURIGA Trial Highlights: Daratumumab + Lenalidomide Maintenance in Newly Diagnosed MM

EP. 4 Transplant-Ineligible NDMM: Updates from CEPHEUS and IMROZ at ASH 2024

EP. 4 Transplant-Ineligible NDMM: Updates from CEPHEUS and IMROZ at ASH 2024

EP. 5 Bispecifics in R/R MM: Key Data and Clinical Implications From ASH 2024 and Ongoing Trials

EP. 5 Bispecifics in R/R MM: Key Data and Clinical Implications From ASH 2024 and Ongoing Trials

EP. 6 Strategic Use of Bispecific Antibodies in R/R MM

EP. 6 Strategic Use of Bispecific Antibodies in R/R MM

EP. 7 Sequencing Bispecifics and BCMA-Targeted Therapies in R/R MM

EP. 7 Sequencing Bispecifics and BCMA-Targeted Therapies in R/R MM

EP. 8 Integrating Bispecific Antibodies Into Clinical Practice

EP. 8 Integrating Bispecific Antibodies Into Clinical Practice

EP. 9 Looking Ahead: Major Clinical Advancements in Myeloma From ASH 2024 and What’s to Come in 2025

EP. 9 Looking Ahead: Major Clinical Advancements in Myeloma From ASH 2024 and What’s to Come in 2025

EP. 10 Developments in CAR T-Cell and Bispecific Therapies in R/R Multiple Myeloma

EP. 10 Developments in CAR T-Cell and Bispecific Therapies in R/R Multiple Myeloma

Video content above is prompted by the following:

Let's now turn our attention to another class of therapies: bispecific antibodies. With several now approved by the FDA and combination trials underway, let's now discuss the landscape of bispecific antibodies—optimal lines of therapy, patient selection, and best practices for integrating these agents into clinical practice.
How are bispecific antibodies reshaping our therapeutic approach in relapsed/refractory multiple myeloma? Walk us through their mechanism of action, currently approved agents, potential advantages, and how these therapies have transformed your clinical decision-making.

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