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Opinion|Videos|February 11, 2025

Sequencing Bispecifics and BCMA-Targeted Therapies in R/R MM

Author(s)Luciano Costa, MD, PhD, Bhagirathbhai Dholaria, MD, Carl Ola Landgren, MD, PhD

Panelists discuss how bispecifics are sequenced with other B-cell maturation antigen (BCMA)–targeted therapies, such as chimeric antigen receptor (CAR) T cells or antibody drug conjugates (ADCs), and whether early vs late relapse impacts treatment strategies for relapsed/refractory multiple myeloma (R/R MM), with emphasis on how biological and clinical factors influence decision-making.

Episodes in this series

EP. 1 Highlights from ASH 2024: Optimizing Frontline Therapy in Transplant-Eligible MM

EP. 1 Highlights from ASH 2024: Optimizing Frontline Therapy in Transplant-Eligible MM

EP. 2 Tailoring Induction Therapy in Newly Diagnosed Transplant-Eligible MM: Key Considerations

EP. 2 Tailoring Induction Therapy in Newly Diagnosed Transplant-Eligible MM: Key Considerations

EP. 3 AURIGA Trial Highlights: Daratumumab + Lenalidomide Maintenance in Newly Diagnosed MM

EP. 3 AURIGA Trial Highlights: Daratumumab + Lenalidomide Maintenance in Newly Diagnosed MM

EP. 4 Transplant-Ineligible NDMM: Updates from CEPHEUS and IMROZ at ASH 2024

EP. 4 Transplant-Ineligible NDMM: Updates from CEPHEUS and IMROZ at ASH 2024

EP. 5 Bispecifics in R/R MM: Key Data and Clinical Implications From ASH 2024 and Ongoing Trials

EP. 5 Bispecifics in R/R MM: Key Data and Clinical Implications From ASH 2024 and Ongoing Trials

EP. 6 Strategic Use of Bispecific Antibodies in R/R MM

EP. 6 Strategic Use of Bispecific Antibodies in R/R MM

EP. 7 Sequencing Bispecifics and BCMA-Targeted Therapies in R/R MM

EP. 7 Sequencing Bispecifics and BCMA-Targeted Therapies in R/R MM

EP. 8 Integrating Bispecific Antibodies Into Clinical Practice

EP. 8 Integrating Bispecific Antibodies Into Clinical Practice

EP. 9 Looking Ahead: Major Clinical Advancements in Myeloma From ASH 2024 and What’s to Come in 2025

EP. 9 Looking Ahead: Major Clinical Advancements in Myeloma From ASH 2024 and What’s to Come in 2025

EP. 10 Developments in CAR T-Cell and Bispecific Therapies in R/R Multiple Myeloma

EP. 10 Developments in CAR T-Cell and Bispecific Therapies in R/R Multiple Myeloma

Video content above is prompted by the following:

How do you approach sequencing bispecifics with other BCMA-targeted therapies, such as CAR T cells or ADCs?
- Does the time frame of relapse—early vs late—alter your treatment sequencing strategies for R/R MM patients?
- How do the biological and clinical characteristics of early vs late relapse influence your decision-making process?

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