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Opinion|Videos|February 4, 2025

Strategic Use of Bispecific Antibodies in R/R MM

Author(s)Luciano Costa, MD, PhD, Bhagirathbhai Dholaria, MD, Carl Ola Landgren, MD, PhD

Panelists discuss at what line of therapy bispecific antibodies are considered in treatment decision-making, whether they are used earlier or later in the sequence, and the factors influencing that choice, including weighing bispecifics against other options like chimeric antigen receptor (chimeric antigen receptor) T or standard therapies. They also address the clinical and molecular factors that guide the selection between B-cell maturation antigen (BCMA)– and GPRC5D-targeting bispecifics and comment on the study exploring talquetamab as a bridging strategy before BCMA CAR T therapy, highlighting the potential impact of bispecifics in this treatment paradigm.

Episodes in this series

EP. 1 Highlights from ASH 2024: Optimizing Frontline Therapy in Transplant-Eligible MM

EP. 1 Highlights from ASH 2024: Optimizing Frontline Therapy in Transplant-Eligible MM

EP. 2 Tailoring Induction Therapy in Newly Diagnosed Transplant-Eligible MM: Key Considerations

EP. 2 Tailoring Induction Therapy in Newly Diagnosed Transplant-Eligible MM: Key Considerations

EP. 3 AURIGA Trial Highlights: Daratumumab + Lenalidomide Maintenance in Newly Diagnosed MM

EP. 3 AURIGA Trial Highlights: Daratumumab + Lenalidomide Maintenance in Newly Diagnosed MM

EP. 4 Transplant-Ineligible NDMM: Updates from CEPHEUS and IMROZ at ASH 2024

EP. 4 Transplant-Ineligible NDMM: Updates from CEPHEUS and IMROZ at ASH 2024

EP. 5 Bispecifics in R/R MM: Key Data and Clinical Implications From ASH 2024 and Ongoing Trials

EP. 5 Bispecifics in R/R MM: Key Data and Clinical Implications From ASH 2024 and Ongoing Trials

EP. 6 Strategic Use of Bispecific Antibodies in R/R MM

EP. 6 Strategic Use of Bispecific Antibodies in R/R MM

EP. 7 Sequencing Bispecifics and BCMA-Targeted Therapies in R/R MM

EP. 7 Sequencing Bispecifics and BCMA-Targeted Therapies in R/R MM

EP. 8 Integrating Bispecific Antibodies Into Clinical Practice

EP. 8 Integrating Bispecific Antibodies Into Clinical Practice

EP. 9 Looking Ahead: Major Clinical Advancements in Myeloma From ASH 2024 and What’s to Come in 2025

EP. 9 Looking Ahead: Major Clinical Advancements in Myeloma From ASH 2024 and What’s to Come in 2025

EP. 10 Developments in CAR T-Cell and Bispecific Therapies in R/R Multiple Myeloma

EP. 10 Developments in CAR T-Cell and Bispecific Therapies in R/R Multiple Myeloma

Video content above is prompted by the following:

At what line of therapy do you consider bispecific antibodies in your treatment decision-making? Are you using them earlier or later in the treatment sequence, and what factors influence that decision?
- How do you weigh bispecific antibodies against other treatment options like CAR T or other standard therapies?
- What clinical and molecular factors do you prioritize when choosing between BCMA- and GPRC5D-targeting bispecifics?
Please comment on this study looking at talquetamab as a bridging strategy before BCMA CAR T-cell therapy, and the potential impact of bispecifics in this treatment paradigm

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