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Opinion|Videos|November 1, 2024

Bispecifics in Relapsed/ Refractory Multiple Myeloma: Combination Strategies, Stepping Up, and Treatment Dose Considerations

Author(s)Saad Z. Usmani, MD, MBA, FACP, Rafael Fonseca, MD, Surbhi Sidana, MD

Panelists discuss the rationale behind combination strategies with bispecifics in relapsed/refractory multiple myeloma (R/R MM), highlighting key studies such as RedirecTT-1 for teclistamab and talquetamab, TRIMM-2 for talquetamab and daratumumab, and MagnetisMM-32 for elranatamab, along with considerations for step-up dosing and outpatient administration protocols.

Episodes in this series

$EP. 1 Current Landscape of Relapsed/ Refractory Multiple Myeloma$

EP. 1 Current Landscape of Relapsed/ Refractory Multiple Myeloma

$EP. 2 Management of Relapsed/Refractory Multiple Myeloma with Bispecifics: MonumenTAL-2, MajesTEC-1, and MagnetisMM-3 trials$

EP. 2 Management of Relapsed/Refractory Multiple Myeloma with Bispecifics: MonumenTAL-2, MajesTEC-1, and MagnetisMM-3 trials

$EP. 3 Bispecifics in Relapsed/ Refractory Multiple Myeloma: Combination Strategies, Stepping Up, and Treatment Dose Considerations$

EP. 3 Bispecifics in Relapsed/ Refractory Multiple Myeloma: Combination Strategies, Stepping Up, and Treatment Dose Considerations

$EP. 4 Treatment Sequencing Strategies for Patients with Relapsed/ Refractory Multiple Myeloma$

EP. 4 Treatment Sequencing Strategies for Patients with Relapsed/ Refractory Multiple Myeloma

$EP. 5 Strategies for Community Adoption of Bispecifics into Treatment of Relapsed/ Refractory Multiple Myeloma$

EP. 5 Strategies for Community Adoption of Bispecifics into Treatment of Relapsed/ Refractory Multiple Myeloma

Video content above is prompted by the following:

Let’s transition to recent updates on combination strategies with bispecifics in R/R MM: What is the rationale for these combination approaches?

RedirecTT-1 for teclistamab andtalquetamab in R/R MM (Cohen et al. IMS 2024. Abstract OA-03/Cohen Y, J Clin Oncol 2023)
TRIMM-2 for talquetamab anddaratumumab in R/R MM (Bahlis et al. IMS 2024. Abstract OA-01. /Dholaria B, J Clin Oncol 2023)
MagnetisMM-32 for elranatamab vs EPd, PVd or Kd (Steven Schuster et al, ASCO 2024 Abstract TPS7576)
How are the step-up and treatment doses for bispecifics administered at your institution? Are they administered in your clinic or in the community?
How are patients monitored for cytokine release syndrome and immune cell-associated neurotoxicity syndrome during step-up dosing?
Please comment on the following studies examining outpatient administration of bispecifics and how these strategies might be incorporated in practice:
OPTec: Outpatient Step-Up Administration of Teclistamab
Ambulatory Teclistamab Administration in R/R MM
What does the process look like for step-up dosing, treatment doses, and monitoring? Are there any variations?

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