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Opinion|Videos|October 18, 2024

Current Landscape of Relapsed/ Refractory Multiple Myeloma

Author(s)Saad Z. Usmani, MD, MBA, FACP, Rafael Fonseca, MD, Surbhi Sidana, MD

Panelists discuss how the current treatment landscape for relapsed/refractory multiple myeloma (R/R MM) includes standard options like such as IMiDs, PIs, and mAbs, while highlighting the emergence of novel therapies such as CAR T- cells and bispecific antibodies, which address unmet needs and offer potential advantages in treatment efficacy and patient outcomes.

Episodes in this series

$EP. 1 Current Landscape of Relapsed/ Refractory Multiple Myeloma$

EP. 1 Current Landscape of Relapsed/ Refractory Multiple Myeloma

$EP. 2 Management of Relapsed/Refractory Multiple Myeloma with Bispecifics: MonumenTAL-2, MajesTEC-1, and MagnetisMM-3 trials$

EP. 2 Management of Relapsed/Refractory Multiple Myeloma with Bispecifics: MonumenTAL-2, MajesTEC-1, and MagnetisMM-3 trials

$EP. 3 Bispecifics in Relapsed/ Refractory Multiple Myeloma: Combination Strategies, Stepping Up, and Treatment Dose Considerations$

EP. 3 Bispecifics in Relapsed/ Refractory Multiple Myeloma: Combination Strategies, Stepping Up, and Treatment Dose Considerations

$EP. 4 Treatment Sequencing Strategies for Patients with Relapsed/ Refractory Multiple Myeloma$

EP. 4 Treatment Sequencing Strategies for Patients with Relapsed/ Refractory Multiple Myeloma

$EP. 5 Strategies for Community Adoption of Bispecifics into Treatment of Relapsed/ Refractory Multiple Myeloma$

EP. 5 Strategies for Community Adoption of Bispecifics into Treatment of Relapsed/ Refractory Multiple Myeloma

Video content above is prompted by the following:

Provide an overview of the current treatment landscape for R/R MM.
Briefly discuss standard treatment options (e.g.eg, IMiDs, PIs,, and mAbs).
Highlight the emergence of novel therapies (eg, CAR T-cells, ADCs antibody-drug conjugates, and bispecifics).
Discuss the unmet needs in R/R MM treatment.
Discuss challenges with current therapies (e.g.eg, resistance, and toxicities).
Discuss patient populations with limited options.
Introduce bispecific antibodies in the context of R/R MM.
Discuss their Basic mechanism of action.
Highlight currently approved bispecifics and those in late-stage development.
Discuss the potential advantages of bispecific antibodies over other treatment modalities.
How has the introduction of bispecifics changed your approach to treating R/R MM?

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