EntreMed’s Thalidomide Analog in Phase I Multiple Myeloma Trial

December 1, 2002
Oncology NEWS International, Oncology NEWS International Vol 11 No 12, Volume 11, Issue 12

ROCKVILLE, Maryland-En-treMed, Inc. has begun a phase I study of its thalidomide derivative ENMD 0995 at the Mayo Clinic, Rochester, Minnesota, in patients with multiple myeloma. ENMD 0995 recently received orphan drug designation from the FDA for the disease.

ROCKVILLE, Maryland—En-treMed, Inc. has begun a phase I study of its thalidomide derivative ENMD 0995 at the Mayo Clinic, Rochester, Minnesota, in patients with multiple myeloma. ENMD 0995 recently received orphan drug designation from the FDA for the disease.

The agent is a small molecular analog of thalidomide with improved angiogenesis inhibitor activity that, in animal models, does not show evidence of the toxic side effects reported for thalidomide, the company said in a news release.