Institutional Implementation: Setting Up Tarlatamab Administration

Summary for Physicians:

Protocol for Tarlatamab Administration:

• Site Setup:
• Pretreatment screening: Ensure patients meet eligibility, assess organ function, and check for contraindications.

• Staff training: Ensure all staff are trained on administration protocols and handling potential toxicities.

• Monitoring: Patients are monitored for immune-related adverse effects such as cytokine release syndrome (CRS), especially during the first dose.

Challenges:

• Management of CRS:
• Need for rapid intervention and close monitoring in case of severe reactions.
• Patient Education:
• Ensuring patients understand potential adverse effects and the importance of timely reporting.
• Infrastructure:

Need for specialized facilities and equipment for infusion and monitoring, especially in the event of adverse reactions.