Institutional Implementation: Setting Up Tarlatamab Administration
Panelists discuss how the administration of tarlatamab requires thorough pretreatment screening, staff training, and close monitoring for immune-related adverse effects such as cytokine release syndrome, emphasizing the importance of patient education, rapid intervention, and specialized infrastructure for safe and effective treatment.
Summary for Physicians:
Protocol for Tarlatamab Administration:
- Site Setup:
- Pretreatment screening: Ensure patients meet eligibility, assess organ function, and check for contraindications.
- Staff training: Ensure all staff are trained on administration protocols and handling potential toxicities.
- Monitoring: Patients are monitored for immune-related adverse effects such as cytokine release syndrome (CRS), especially during the first dose.
Challenges:
- Management of CRS:
- Need for rapid intervention and close monitoring in case of severe reactions.
- Patient Education:
- Ensuring patients understand potential adverse effects and the importance of timely reporting.
- Infrastructure:
Need for specialized facilities and equipment for infusion and monitoring, especially in the event of adverse reactions.
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