Future Research Priorities: Optimizing Tarlatamab Administration and Toxicity Management

Summary for Physicians:

Future Research Priorities:

• Optimizing tarlatamab administration:
• Investigate dose optimization and scheduling to maximize efficacy while minimizing toxicity.

• Explore combination therapies with other immunotherapies or targeted agents for synergistic effects.
• Toxicity management:
• Develop predictive biomarkers for early detection of cytokine release syndrome and immune effector cell–associated neurotoxicity syndrome.

• Improve management protocols to reduce the incidence of severe toxicities.

• Investigate strategies to minimize neurological and immune-related adverse events without compromising efficacy.

Long-Term Goals:

• Enhance patient selection strategies to identify those most likely to benefit from tarlatamab.

Evaluate long-term safety and effectiveness in real-world settings.