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Opinion|Videos|May 29, 2025

Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue

Panelists discuss how the assessment and management of immune effector cell–associated neurotoxicity syndrome involves grading symptoms from mild to life-threatening, emphasizing the need for prompt recognition and rapid intervention to prevent progression and minimize long-term neurological damage.

Episodes in this series

Summary for Physicians:

Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue

  • Dysgeusia (altered taste):
  • Common adverse effect, particularly with chemotherapy and immunotherapy

  • Management:

  • Recommend small, frequent meals with strong flavors (eg, citrus, mint).

  • Suggest using plastic utensils to minimize taste alteration.

  • Encourage good oral hygiene to reduce taste disturbances.
  • Fatigue:
  • Frequently reported, can be persistent and impact quality of life

  • Management:

  • Energy conservation techniques (eg, rest periods, prioritizing tasks)

  • Exercise programs to improve stamina and reduce fatigue

  • Monitor for underlying causes such as anemia or dehydration

  • Address sleep hygiene and manage emotional stress

Challenges:

Both symptoms can be challenging to manage long term, requiring personalized strategies and regular assessment.

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