Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue
Panelists discuss how the assessment and management of immune effector cell–associated neurotoxicity syndrome involves grading symptoms from mild to life-threatening, emphasizing the need for prompt recognition and rapid intervention to prevent progression and minimize long-term neurological damage.
Summary for Physicians:
Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue
- Dysgeusia (altered taste):
- Common adverse effect, particularly with chemotherapy and immunotherapy
- Management:
- Recommend small, frequent meals with strong flavors (eg, citrus, mint).
- Suggest using plastic utensils to minimize taste alteration.
- Encourage good oral hygiene to reduce taste disturbances.
- Fatigue:
- Frequently reported, can be persistent and impact quality of life
- Management:
- Energy conservation techniques (eg, rest periods, prioritizing tasks)
- Exercise programs to improve stamina and reduce fatigue
- Monitor for underlying causes such as anemia or dehydration
- Address sleep hygiene and manage emotional stress
Challenges:
Both symptoms can be challenging to manage long term, requiring personalized strategies and regular assessment.
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