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Opinion|Videos|May 22, 2025

Essential Patient and Caregiver Education for Tarlatamab Treatment Success

Author(s)Samuel Rosner, MD, Ranee Mehra, MD, Michelle Sittig, RN, OCN

Panelists discuss how education materials for tarlatamab include detailed treatment overviews, potential adverse effects, and monitoring requirements, while emphasizing the importance of ensuring that patients and caregivers fully understand the information and can recognize early signs of adverse reactions.

Episodes in this series

EP. 1 ES-SCLC vs LS-SCLC: Critical Differences in Disease Burden and Patient Prognosis

EP. 1 ES-SCLC vs LS-SCLC: Critical Differences in Disease Burden and Patient Prognosis

EP. 2 Current Treatment Paradigm: Evolution of First-Line Therapy for ES-SCLC

EP. 2 Current Treatment Paradigm: Evolution of First-Line Therapy for ES-SCLC

EP. 3 Addressing Critical Unmet Needs in ES-SCLC Patient Management

EP. 3 Addressing Critical Unmet Needs in ES-SCLC Patient Management

EP. 4 Emerging Clinical Trials: Novel Approaches in Second-Line ES-SCLC

EP. 4 Emerging Clinical Trials: Novel Approaches in Second-Line ES-SCLC

EP. 5 Institutional Implementation: Setting Up Tarlatamab Administration

EP. 5 Institutional Implementation: Setting Up Tarlatamab Administration

EP. 6 Optimizing Multidisciplinary Coordination for Successful Tarlatamab Implementation

EP. 6 Optimizing Multidisciplinary Coordination for Successful Tarlatamab Implementation

EP. 7 Patient Selection Criteria: Identifying Appropriate Candidates for Tarlatamab

EP. 7 Patient Selection Criteria: Identifying Appropriate Candidates for Tarlatamab

EP. 8 Tarlatamab Administration and Postinfusion Monitoring

EP. 8 Tarlatamab Administration and Postinfusion Monitoring

EP. 9 Essential Patient and Caregiver Education for Tarlatamab Treatment Success

EP. 9 Essential Patient and Caregiver Education for Tarlatamab Treatment Success

EP. 10 Neurological Toxicity Recognition: ICANS Assessment and Management

EP. 10 Neurological Toxicity Recognition: ICANS Assessment and Management

EP. 11 CRS Recognition and Intervention: Timing and Clinical Features

EP. 11 CRS Recognition and Intervention: Timing and Clinical Features

EP. 12 Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue

EP. 12 Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue

EP. 13 Differential Toxicity Profile: Tarlatamab vs Traditional Cytotoxic Therapies

EP. 14 Standardized Toxicity Grading: Institutional Protocols for CRS and ICANS

EP. 14 Standardized Toxicity Grading: Institutional Protocols for CRS and ICANS

EP. 15 Future Research Priorities: Optimizing Tarlatamab Administration and Toxicity Management

EP. 15 Future Research Priorities: Optimizing Tarlatamab Administration and Toxicity Management

EP. 16 Seamless Transitions: Managing the Inpatient to Outpatient Care Continuum

EP. 16 Seamless Transitions: Managing the Inpatient to Outpatient Care Continuum

EP. 17 Complex ES-SCLC Case: Tarlatamab Management Through Toxicity to Clinical Benefit

EP. 17 Complex ES-SCLC Case: Tarlatamab Management Through Toxicity to Clinical Benefit

Summary for Physicians:

Education Materials/Resources Provided:

Treatment overview:
Detailed explanation of tarlatamab, its purpose, and expected benefits.

Overview of the administration process and frequency of infusions.
Potential adverse effects:
Information on common adverse effects (eg, fever, fatigue) and serious adverse events (eg, cytokine release syndrome).

Signs and symptoms to watch for, and when to seek immediate medical attention.
Monitoring requirements:
Postinfusion monitoring expectations (eg, observation for 1-2 hours after infusion).

Follow-up appointments and any additional monitoring required.
Support resources:
Access to 24/7 nursing support for urgent questions or concerns.

Contact information for the pharmacy and oncology team.

Challenges:

Ensuring patients and caregivers fully understand the information and know how to recognize early signs of adverse reactions.

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