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Opinion|Videos|September 6, 2024

Long-Term Follow-Up of MonumenTAL-1

Author(s)Ajai Chari, MD, Noopur Raje, MD, Rafael Fonseca, MD

Larysa J. Sanchez, MD, discusses recent efficacy data presented at EHA 2024 from the long-term follow-up results of the phase 1/2 MonumenTAL-1 study investigating talquetamab in relapsed/refractory multiple myeloma.

Episodes in this series

A panel of 4 experts on multiple myeloma

EP. 1 Significance of GPRC5D as a Target for R/R MM

A panel of 4 experts on multiple myeloma

EP. 2 Long-Term Follow-Up of MonumenTAL-1

A panel of 4 experts on multiple myeloma

EP. 3 MonumenTAL-1: Efficacy and Safety Data

A panel of 4 experts on multiple myeloma

EP. 4 Broader Implications and Current Trials of GPRC5D-Targeted Treatments in Relapsed/Refractory Multiple Myeloma

A panel of 4 experts on multiple myeloma

EP. 5 Overview of MonumenTAL-2 and MonumenTAL-3

A panel of 4 experts on multiple myeloma

EP. 6 Evaluating Combination Strategies in R/R MM: TRIMM-2, TRIMM-3, MajesTEC-3

EP. 7 Exploring GPRC5D as an Important Target for Multiple Myeloma

EP. 7 Exploring GPRC5D as an Important Target for Multiple Myeloma

A panel of 4 experts on multiple myeloma

EP. 8 Overview of RedirecTT-1, MagnetisMM-30 and MagnetisMM-5

A panel of 4 experts on multiple myeloma

EP. 9 Implications of Combination Regimens for R/R MM

A panel of 4 experts on multiple myeloma

EP. 10 Overview of Recent Updates in Bispecific Therapy in R/R MM

A panel of 4 experts on multiple myeloma

EP. 11 Impact of T-cell Affinity in Bispecific Therapy in R/R MM

Video content above is prompted by the following:

Please discuss the efficacy data, focusing on PFS and DOR, presented at EHA 2024 on the long-term follow-up results of the phase 1/2 MonumenTAL-1 study of talquetamab in patients with RRMM.
- What factors might contribute to the longer DOR with Q2W dosing compared to QW dosing in patients naive to prior TCR?

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