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Opinion|Videos|June 29, 2026 (Updated: June 29, 2026)

MARIPOSA Trial: EGFR-Mutant Lung Cancer Frontline Strategies

Author(s)Edgardo Santos, MD, FACP, FASCO, Misako Nagasaka, MD, PhD, Estelamari Rodriguez, MD, MPH

Panelists discuss the pivotal MARIPOSA trial, which examined combining amivantamab with lazertinib versus osimertinib monotherapy, showing improvements in progression-free survival (23.7 vs. 16.6 months), overall survival, CNS efficacy, and particularly strong benefits in high-risk subgroups such as TP53-mutant patients. Safety data from the trial highlighted the importance of prophylactic measures, especially for rash and other adverse events, noting that with current prophylaxis protocols, serious toxicity rates have been significantly reduced compared to the original study.

Episodes in this series

Experts featured in this series.

EP. 1 MARIPOSA Trial: EGFR-Mutant Lung Cancer Frontline Strategies

Experts featured in this series.

EP. 2 MARIPOSA Prophylaxis, Biomarkers, and CNS Debate

Panelists discuss the pivotal MARIPOSA trial, which examined combining amivantamab with lazertinib versus osimertinib monotherapy, showing improvements in progression-free survival (23.7 vs. 16.6 months), overall survival, CNS efficacy, and particularly strong benefits in high-risk subgroups such as TP53-mutant patients. Safety data from the trial highlighted the importance of prophylactic measures, especially for rash and other adverse events, noting that with current prophylaxis protocols, serious toxicity rates have been significantly reduced compared to the original study.

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MARIPOSA Prophylaxis, Biomarkers, and CNS Debate

ByEdgardo Santos, MD, FACP, FASCO,Misako Nagasaka, MD, PhD,Estelamari Rodriguez, MD, MPH,Luis Raez, MD,Mary Jo Fidler, MD,Hatim Husain, MD,Jonathan Riess, MD, MS

Published: June 29th 2026 | Updated: June 29th 2026

Clinical Scenario 1: High-Risk Adjuvant Setting in cSCC Treatment

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MAIA Efficacy and MRD Outcomes in Newly Diagnosed Multiple Myeloma

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MAIA Long-Term Outcomes in Newly Diagnosed Multiple Myeloma

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Real-World Data and Neoadjuvant Use in cSCC

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