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Opinion|Videos|January 23, 2025

Overview of FLAURA and MARIPOSA-2 Clinical Trials

Author(s)Rajat Thawani, MD, MBBs , Edward S. Kim, MD, MBA, Edward B. Garon, MD, MS

Dr. Kim reviews key clinical evidence from the FLAURA trial for osimertinib as a first-line therapy in EGFR+ metastatic NSCLC and discusses the MARIPOSA 2 trial supporting amivantamab with chemotherapy as the preferred second-line option.

Episodes in this series

6 experts are featured in this series.

EP. 1 Robert’s Journey With EGFR+ Metastatic NSCLC

6 experts are featured in this series.

EP. 2 The Impact of Molecular Testing on Treatment Choices for NSCLC

6 experts are featured in this series.

EP. 3 Overview of FLAURA and MARIPOSA-2 Clinical Trials

6 experts are featured in this series.

EP. 4 Clinical Experience of Amivantamab in EGFR+ NSCLC Patients

6 experts are featured in this series.

EP. 5 Factors in Selecting Treatment Options for EGFR+ NSCLC

6 experts are featured in this series.

EP. 6 Evaluating Treatment Options of EGFR Inhibitors

6 experts are featured in this series.

EP. 7 Considerations for Second-Line Treatment Decisions in EGFR+ NSCLC: Sequencing Strategies and First-Line Choices

6 experts are featured in this series.

EP. 8 Jason’s Journey with ALK+ Metatstatic NSCLC

6 experts are featured in this series.

EP. 9 Barriers and Challenges in Biomarker Testing for ALK+ NSCLC

6 experts are featured in this series.

EP. 10 Overview of Efficacy of Lorlatinib in the Treatment of ALK+ NSCLC

6 experts are featured in this series.

EP. 11 Overview of Current Treatment Landscape of ALK Inhibitors

6 experts are featured in this series.

EP. 12 Clinical Experience of Lorlatinib ALK+ NSCLC Patients

6 experts are featured in this series.

EP. 13 Patient Factors Considered when Choosing Treatment Selection

6 experts are featured in this series.

EP. 14 Treatment Strategies in Disease Progression in ALK+ NSCLC

6 experts are featured in this series.

EP. 15 Evaluating ALK Inhibitors in Treatment Sequencing and Testing

6 experts are featured in this series.

EP. 16 Future Therapies for ALK+ Metastatic NSCLC

Video content above is prompted by the following:

Provide an overview of the clinical evidence from the FLAURA trial supporting osimertinib as a first-line treatment for EGFR+ metastatic NSCLC.
Review the evidence from the MARIPOSA-2 trial supporting amivantamab plus chemotherapy as the best second-line option for this patient.

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