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Opinion|Videos|January 24, 2025

Overview of the CAR T-Cell Therapy Process: Apheresis, Manufacturing, Potential Bridging Therapies, Lymphodepletion, and Infusion

Author(s)Saad Z. Usmani, MD, MBA, FACP, Carlyn Rose Tan, MD , Sham Mailankody, MBBS

Panelists discuss how chimeric antigen receptor (CAR) T-cell therapy’s mechanism of action and treatment workflow requires extensive institutional coordination, from patient selection through bridging therapy and infusion, with varied approaches to managing patients during the manufacturing period across different centers.

Episodes in this series

4 experts are featured in this series.

EP. 1 Highlighted Data Review of CAR-T in Early R/R MM

4 experts are featured in this series.

EP. 2 Expert Insights: Distinguishing between CARTITUDE-4 vs. KarMMa-3 Trials

4 experts are featured in this series.

EP. 3 CAR-T in R/R MM: Patient Selection & Treatment Sequencing

4 experts are featured in this series.

EP. 4 CAR-T in Earlier Lines of MM Treatment: Patient Eligibility - Considerations between Ide-cel vs. Cilta-cel

4 experts are featured in this series.

EP. 5 MSKCC Insights: CAR T Referral Process

4 experts are featured in this series.

EP. 6 Overview of the CAR T-Cell Therapy Process: Apheresis, Manufacturing, Potential Bridging Therapies, Lymphodepletion, and Infusion

4 experts are featured in this series.

EP. 7 Collaboration With Community Colleagues: Comanagement and Transitions of Care

4 experts are featured in this series.

EP. 8 CAR T Referral Process: Challenges Seen and How They Can Be Addressed

4 experts are featured in this series.

EP. 9 MSKCC Experiences: Successful CAR T Collaborations With Community and International Providers

4 experts are featured in this series.

EP. 10 CAR-T Clinical Trials: Potentially Moving CAR T Into Earlier Lines of MM Treatment

4 experts are featured in this series.

EP. 11 Applying Evidence to Clinical Practice: 63-Year-Old Patient With R/R MM Post Dara-VRd Induction Scenario

4 experts are featured in this series.

EP. 12 CAR T in R/R MM: Key Takeaways and Pearls

Video content above is prompted by the following:

Could you explain how CAR T-cell therapy works and describe the treatment process?
- Do you consider CAR T therapy a complex process at your institution, or have you been able to streamline the logistics and integration into clinical workflows?
Dr Usmani to ask Dr Mailankody: Can you explain your institution’s approach to bridging therapy for patients awaiting CAR-T manufacturing and infusion?
- Do you send patients back to community center or does it happen in-house?

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