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Opinion|Videos|January 14, 2025

PI3K Inhibitors, Oral SERDs, Combination Therapies, and the Shifting Treatment Landscape

Author(s)Virginia Kaklamani, MD, DSc, Claudine Isaacs, MD, Elizabeth Diaz, NP

Panelists discuss ongoing clinical trials and how the treatment landscape for HR positive (HR+)/ HER2 negative (HER2-) breast cancer is evolving with novel targeted therapies and combination strategies, with Dr Isaacs highlighting the most exciting aspects of these trials and their potential impact on the future of precision medicine in this patient population.

Episodes in this series

EP. 1 Precision Pathways: Emerging Targeted Therapies in HR+/HER2- Breast Cancer

EP. 1 Precision Pathways: Emerging Targeted Therapies in HR+/HER2- Breast Cancer

EP. 2 INAVO120 Trial Insights and Inavolisib's Emerging Role in the Treatment Armamentarium

EP. 2 INAVO120 Trial Insights and Inavolisib's Emerging Role in the Treatment Armamentarium

EP. 3 Precision Pathways: Targeted Therapies, Mutation-Driven Treatment Strategies

EP. 3 Precision Pathways: Targeted Therapies, Mutation-Driven Treatment Strategies

EP. 4 Biomarker Testing Best Practices for Informed Treatment Decision-Making: Med Onc and Nurse Perspectives

EP. 4 Biomarker Testing Best Practices for Informed Treatment Decision-Making: Med Onc and Nurse Perspectives

EP. 5 Adapting Biomarker Testing Practices as Targeted Therapies Shift to Earlier Lines of Treatment

EP. 5 Adapting Biomarker Testing Practices as Targeted Therapies Shift to Earlier Lines of Treatment

EP. 6 Hyperglycemia Monitoring and AIC Monitoring with PI3K/AKT Pathway Inhibitors: Practical Approaches and Strategies

EP. 6 Hyperglycemia Monitoring and AIC Monitoring with PI3K/AKT Pathway Inhibitors: Practical Approaches and Strategies

EP. 7 Treatment Decision-Making in PIK3CA-mut HR+/HER2- Breast Cancer: Key Tolerability Considerations

EP. 7 Treatment Decision-Making in PIK3CA-mut HR+/HER2- Breast Cancer: Key Tolerability Considerations

EP. 8 Strategies for Staying Informed and Coordinating Care as New Agents Emerge in HR+/HER2- Breast Cancer

EP. 8 Strategies for Staying Informed and Coordinating Care as New Agents Emerge in HR+/HER2- Breast Cancer

EP. 9 PI3K Inhibitors, Oral SERDs, Combination Therapies, and the Shifting Treatment Landscape

EP. 9 PI3K Inhibitors, Oral SERDs, Combination Therapies, and the Shifting Treatment Landscape

Video content above is prompted by the following:

Dr Kaklamani asks Dr Isaacs: Please highlight ongoing trials and comment on how the landscape is evolving with novel targeted therapies and combinations. What aspects of these trials are most exciting for the future of precision medicine in HR+/HER2- breast cancer?

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