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Opinion|Videos|April 28, 2025

Potential Role of Tumor-Informed ctDNA in CRC

Author(s)John L. Marshall, MD, Mark Lewis, MD

Panelists discuss how tumor-informed circulating tumor DNA (ctDNA) testing offers a personalized molecular surveillance strategy that can revolutionize colorectal cancer management through earlier detection of recurrence, real-time monitoring of treatment response, and potential for therapy de-escalation in patients with negative results.

Episodes in this series

2 experts are featured in this series.

EP. 1 The Role of ctDNA in CRC

2 experts are featured in this series.

EP. 2 BESPOKE: Study Design, Efficacy End Points, and Methods

2 experts are featured in this series.

EP. 3 Overview of BESPOKE Patient Characteristics

2 experts are featured in this series.

EP. 4 BESPOKE: Highlighting the Disease-Free Survival by ctDNA Status

2 experts are featured in this series.

EP. 5 BESPOKE: ctDNA Clearance During and After ACT

2 experts are featured in this series.

EP. 6 Role of MRD Status in Treatment Intensification or De-Escalation of Adjuvant Therapy

2 experts are featured in this series.

EP. 7 SWOG 80702: Overview of Study Design, Efficacy End Points, and Patient Characteristics

2 experts are featured in this series.

EP. 8 SWOG 80702: Impressions on the Efficacy Data

2 experts are featured in this series.

EP. 9 Potential Role of Tumor-Informed ctDNA in CRC

2 experts are featured in this series.

EP. 10 Importance of Patient-Centric Approach and Patient Education of ctDNA Testing in CRC and Looking Ahead

2 experts are featured in this series.

EP. 11 The Role of ctDNA Testing in Colorectal Cancer Management: Exploring Its Use Alongside Imaging in Challenging Cases

2 experts are featured in this series.

EP. 12 Research Considerations for ctDNA Testing in Colorectal Cancer

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