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Opinion|Videos|January 23, 2025

Proactively Managing Toxicities in RCC IO/TKI Combinations: Insights and Recommendations

Author(s)Hannah Dzimitrowicz McManus, MD , Allison Brown, BSN, RN, RN-BC

Panelists discuss essential patient education when initiating combination regimens for RCC, addressing overlapping and unique toxicity considerations in IO/TKI combinations, counseling strategies for monitoring and communicating potential adverse events (AEs), key AEs for patients to watch for, and strategies for proactive toxicity mitigation and management.

Episodes in this series

EP. 1 Understanding Advanced RCC: Epidemiology, Presentation, and Risk Stratification

EP. 1 Understanding Advanced RCC: Epidemiology, Presentation, and Risk Stratification

EP. 2 James’ Journey with Clear Cell RCC: Diagnosis, Early Challenges, and His Treatment Journey

EP. 2 James’ Journey with Clear Cell RCC: Diagnosis, Early Challenges, and His Treatment Journey

EP. 3 The Role of the Multidisciplinary Care Team in RCC

EP. 3 The Role of the Multidisciplinary Care Team in RCC

EP. 4 Exploring Standards of Care and Treatment Goals in Advanced Clear Cell RCC

EP. 4 Exploring Standards of Care and Treatment Goals in Advanced Clear Cell RCC

EP. 5 Selecting the Right RCC Treatment Plan: Shared Decision-Making and Expert Advice

EP. 5 Selecting the Right RCC Treatment Plan: Shared Decision-Making and Expert Advice

EP. 6 Key Clinical Trial Data and Insights in Advanced Clear Cell RCC

EP. 6 Key Clinical Trial Data and Insights in Advanced Clear Cell RCC

EP. 7 Proactively Managing Toxicities in RCC IO/TKI Combinations: Insights and Recommendations

EP. 7 Proactively Managing Toxicities in RCC IO/TKI Combinations: Insights and Recommendations

EP. 8 Frontline Treatment Strategies in Non–Clear Cell RCC: Emerging Data and Trials

EP. 8 Frontline Treatment Strategies in Non–Clear Cell RCC: Emerging Data and Trials

EP. 9 Enhancing Supportive Care and Quality of Life for RCC Patients

EP. 9 Enhancing Supportive Care and Quality of Life for RCC Patients

EP. 10 Improving the RCC Patient Journey and Future Therapeutic Directions

EP. 10 Improving the RCC Patient Journey and Future Therapeutic Directions

EP. 11 Clinicians Consider Identification, Management of RCC Through the Patient’s Eyes

EP. 11 Clinicians Consider Identification, Management of RCC Through the Patient’s Eyes

Video content above is prompted by the following:

From a nursing perspective, what patient education is essential when initiating these combination regimens?
- When treating patients with RCC with IO/TKI combinations, what are the overlapping and unique toxicity considerations?
- How do you counsel patients about monitoring and communicating regarding potential adverse events? Which AEs are most important for patients to look out for?
- What strategies do you recommend for proactive toxicity mitigation and management?
From a patient perspective, what information is essential for patients to understand when receiving pembrolizumab plus lenvatinib?
- Which adverse effects did you experience while on treatment, and how did you manage these?
- What was the role of your care team in managing adverse effects and counseling you throughout treatment?

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