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Opinion|Videos|November 16, 2023

Teclistamab plus Nirogacestat in RRMM: The MAJESTEC-2 Study

Author(s)Carolina D. Schinke, MD, Joselle Cook, M.B.B.S, Luciano Costa, MD, PhD

Drs Luciano Costa and Binod Dhakal discuss combining bispecific antibodies with gamma secretase inhibitors for the treatment of relapsed/refractory multiple myeloma, but trials show limited benefit and added toxicity; more promising are combinations with immunomodulators like isatuximab.

Episodes in this series

EP. 1 Patient Case Presentation: A 47-Year-Old Man With Multiple Myeloma

EP. 1 Patient Case Presentation: A 47-Year-Old Man With Multiple Myeloma

$EP. 2 Treatment Options for Patients With Relapsed/Refractory Multiple Myeloma (RRMM)$

EP. 2 Treatment Options for Patients With Relapsed/Refractory Multiple Myeloma (RRMM)

EP. 3 Talquetamab in RRMM: Results From MonumenTAL-1

EP. 3 Talquetamab in RRMM: Results From MonumenTAL-1

EP. 4 Teclistamab Plus Talquetamab in RRMM: Data from the RedirecTT-1 Study

EP. 4 Teclistamab Plus Talquetamab in RRMM: Data from the RedirecTT-1 Study

EP. 5 Teclistamab plus Nirogacestat in RRMM: The MAJESTEC-2 Study

EP. 5 Teclistamab plus Nirogacestat in RRMM: The MAJESTEC-2 Study

EP. 6 Bispecific-Based Combinations Under Evaluation for Patients with RRMM

EP. 6 Bispecific-Based Combinations Under Evaluation for Patients with RRMM

EP. 7 Toxicity Management in Patients With RRMM Receiving Bispecific Antibodies

EP. 7 Toxicity Management in Patients With RRMM Receiving Bispecific Antibodies

EP. 8 Treatment Approaches for Frail Patients With RRMM

EP. 8 Treatment Approaches for Frail Patients With RRMM

EP. 9 Patient Case Presentation: A 62-Year-Old Woman With High-Risk Multiple Myeloma

EP. 9 Patient Case Presentation: A 62-Year-Old Woman With High-Risk Multiple Myeloma

EP. 10 Available Options for CAR T-Cell Therapy in Patients With RRMM

EP. 10 Available Options for CAR T-Cell Therapy in Patients With RRMM

EP. 11 Ciltacabtagene Autoleucel in Patients With MM: Efficacy and Safety Data From CARTITUDE-1

EP. 11 Ciltacabtagene Autoleucel in Patients With MM: Efficacy and Safety Data From CARTITUDE-1

EP. 12 Clinical Pearls for Community Physicians Treating Patients With RRMM With CAR T-Cell Therapy

EP. 12 Clinical Pearls for Community Physicians Treating Patients With RRMM With CAR T-Cell Therapy

EP. 13 Toxicity Management in Patients With R/R MM Receiving CAR T-Cell Therapy

EP. 13 Toxicity Management in Patients With R/R MM Receiving CAR T-Cell Therapy

EP. 14 Exploring Novel Treatment Options in Patients With RRMM

EP. 14 Exploring Novel Treatment Options in Patients With RRMM

EP. 15 Analyzing a Patient Case and Assessing Treatment After Relapse in Multiple Myeloma

EP. 15 Analyzing a Patient Case and Assessing Treatment After Relapse in Multiple Myeloma

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Beth Faiman, PhD, MSN, APN-BC, BMTCN, AOCN, FAAN, FAPO; Beth Sandy, MSN, CRNP, FAPO; Lindsay Adkins, MSN, FNP-BC, BMTCN; Jeneth Aquino, DNP, FNP-BC; Casey Gormley, MSN, FNP-C, AOCNP; Heather J. Jackson, PhD, FNP-BC; Kelsey Martin, AG-ACNP-BC, AOCNP; Nerina T. McDonald, PA-C; Lauren Verity Moore, DNP, MSN, AGACNP-BC; Faith A. Mutale, DNP, CRNP; Tiffany Richards, PhD, ANP-BC, AOCNP; Emily Skotte, DNP, MSN, ACNP-BC; Leslie Smith, DNP, RN, APRN-CNS, AOCNS, BMTCN; Saneese Stephen, PA-C, MPAS; Sara M. Tinsley-Vance, PhD, APRN, AOCN

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Community Practice Connections™: DLL3-Targeting Bispecific Antibodies for Small Cell Lung Cancer—From Innovation to Practice

Community Practice Connections™: DLL3-Targeting Bispecific Antibodies for Small Cell Lung Cancer—From Innovation to Practice

Jacob Sands, MD; Anne Chiang, MD, PhD

Hot Seat: How Experts Are Integrating the Latest Practice-Changing Data Into Their Breast Cancer Clinics

Hot Seat: How Experts Are Integrating the Latest Practice-Changing Data Into Their Breast Cancer Clinics

Tiffany A. Traina, MD, FASCO; Nour Abuhadra, MD; Joshua Z. Drago, MD, MS; Ruth O’Regan, MD; Vered Stearns, MD, FASCO; Neil Vasan, MD, PhD; Anna Weiss, MD

Cases and Conversations™: Transforming Small Cell Lung Cancer Treatment Through Emerging Evidence and Expert Insights

Cases and Conversations™: Transforming Small Cell Lung Cancer Treatment Through Emerging Evidence and Expert Insights

Charles M. Rudin, MD, PhD; Anne Chiang, MD, PhD, FASCO; Jacob M. Sands, MD

(Pharmacist Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

(Pharmacist Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

Michelle L. Taylor, ANP-BC; Emely Alfaro, DNP, RN, CNS, OCN; Paige Griffith, CRNP; Beth Sandy, MSN, CRNP, FAPO

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