Teclistamab plus Nirogacestat in RRMM: The MAJESTEC-2 Study

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Drs Luciano Costa and Binod Dhakal discuss combining bispecific antibodies with gamma secretase inhibitors for the treatment of relapsed/refractory multiple myeloma, but trials show limited benefit and added toxicity; more promising are combinations with immunomodulators like isatuximab.

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Patients treated with BCMA-directed immunotherapies for myeloma may experience susceptibility to severe infections following treatment.
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