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Opinion|Videos|January 26, 2026

Translating Early Intervention into Real-World Care for High-Risk Smoldering Multiple Myeloma

Author(s)Larry Anderson, MD, PhD, Caitlin Costello, MD, Laahn Foster, MD

Explore the evolving landscape of smoldering myeloma treatment, focusing on fixed-duration therapy and patient-provider communication strategies.

Episodes in this series

3 panelists

EP. 1 Emerging Therapeutic Strategies in High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 2 Evolving Definitions and Risk Gaps in High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 3 Unmet Clinical Needs Driving Early Intervention in High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 4 Understanding the AQUILA Study Design in High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 5 Interpreting Baseline Profiles and PFS Outcomes in High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 6 Evaluating Early Survival Signals and Treatment Timing in High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 7 Safety Considerations for Subcutaneous Daratumumab in High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 8 Positioning AQUILA Among Early-Intervention Strategies for High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 9 Translating Early Intervention into Real-World Care for High-Risk Smoldering Multiple Myeloma

3 panelists

EP. 10 Integrating AQUILA Findings into Care for High-Risk Smoldering Multiple Myeloma

This segment shifts the discussion from clinical trial data to real-world application, focusing on how early intervention strategies may be integrated into routine care for patients with high-risk smoldering multiple myeloma. Faculty discuss practical considerations such as identifying appropriate candidates for treatment, aligning therapy duration with patient goals, and incorporating subcutaneous administration into existing clinical workflows.

Panelists explore how trial-based monitoring requirements compare with real-world practice, including strategies for follow-up, toxicity surveillance, and patient education. The conversation also addresses how clinicians communicate the rationale for early intervention to asymptomatic patients and support shared decision-making in this setting.

By examining implementation challenges and opportunities, this segment highlights the importance of individualized care and practice-level considerations when translating AQUILA findings into everyday clinical management.

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