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Opinion|Videos|May 9, 2024

Treating Transplant-Ineligible Patients With HCC and Liver-Confined Disease

Author(s)Rahul Gosain, MD, Rohit Gosain, MD, Nina Sanford, MD

Focusing on liver-directed therapy, the panel provides clinical insights on the treatment of patients with hepatocellular carcinoma who have liver-confined disease and are not candidates for transplant.

Episodes in this series

A panel of 5 experts on liver cancer

EP. 1 The Basics of Radiation Oncology

A panel of 5 experts on liver cancer

EP. 2 Overview of Interventional Radiology Treatment Options

A panel of 5 experts on liver cancer

EP. 3 Treating Transplant-Ineligible Patients With HCC and Liver-Confined Disease

A panel of 5 experts on liver cancer

EP. 4 Adverse Effects Associated with SBRT in Patients With HCC

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

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A phase 1 trial evaluating PLT012 in HCC, among other solid tumors, is currently underway and will report safety and preliminary clinical activity data.

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Rivoceranib plus camrelizumab achieved a median OS of 23.8 months vs 15.2 months with sorafenib alone in patients with unresectable hepatocellular carcinoma.

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Following 2 prior CRLs from the FDA for the rivoceranib plus camrelizumab regimen in frontline HCC, the developer has again submitted an NDA to the FDA.

Developers Resubmit NDA for Rivoceranib/Camrelizumab in Unresectable HCC

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Early data from the ABC-HCC trial showed an improvement in median time to failure of strategy with atezolizumab/bevacizumab vs TACE in this HCC population.

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January 9th 2026

BGB-B2033 is under evaluation for patients with hepatocellular carcinoma who progressed on or after systemic therapy in a first-in-human phase 1 trial.

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