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Karen Suchanek Hudmon, DrPH
Latest Article

Promoting Smoking Cessation Among Cancer Patients: A Behavioral Model

The smoking cessation clinical practice guideline recently published by the Agency for Health Care Policy and Research (AHCPR) summarizes current knowledge on smoking cessation treatments. Among its

Karen Taylor, RN, MS
Latest Article

Management of Delirium

Ms. B is a 44-year-old married African-American female who was diagnosed with locally advanced right breast cancer in 2002. Immunohistochemistry in the original tumor was estrogen- and progesterone-receptor-negative, HER2-positive. Her past medical history is significant for hypertension and miscarriage in 1995.

Karen Ventii, PhD
Latest Article

New Biomarkers in Prostate Cancer

In this article, we review recent advances in the discovery of prostate cancer biomarkers, their integration into clinical practice, and implications for improving clinical management of the disease.

Karen Weiss, MD
Latest Article

Deferasirox for the Treatment of Chronic Iron Overload in Transfusional Hemosiderosis

This report describes the Food and Drug Administration's review of data and analyses leading to the approval of the oral iron chelator, deferasirox for the treatment of chronic iron overload due to transfusional hemosiderosis.

Kari B. Wisinski, MD
Latest Article

77 Updated Efficacy of Mutant-Selective PI3Kα Inhibitor Zovegalisib (RLY-2608) in Combination With Fulvestrant in Patients With PIK3CA-Mutant HR+/HER2– Advanced Breast Cancer: ReDiscover Trial

Zovegalisib plus fulvestrant demonstrated an objective response rate of 38.7% and a median progression-free survival of 10.3 months in PIK3CA-mutant HR+/HER2– advanced breast cancer in the ReDiscover trial.

Karim Bensaad, PhD
Latest Article

Cancer Metabolism as a Therapeutic Target: Metabolic Synthetic Lethality

Drugs targeting different metabolic pathways induced in tumors may be used in combination with one another to induce synthetic lethality in cancer cells, while preserving the survival of normally proliferating cells.

Karime K. Machado, MD
Latest Article

Autonomy Versus Paternalism in Latin America

In this paper, Dr. Cherny beautifully reviews how to balance the patient's right to be adequately informed about his or her disease with the powerful cultural beliefs held in many parts of the world.

Karin B. Olson, PA-C
Latest Article

Use of Bisphosphonates in the Treatment of Prostate Cancer

Recently, there has been much controversy over whether patients with prostate cancer should be treated with bisphosphonates not only to decrease pain, but to prevent metastasis.

Karin Gwyn, MD, MSC
Latest Article

Breast Cancer During Pregnancy

The care of a pregnant breast cancer patient is a challenging clinical situation that historically has placed the welfare of the mother in conflict with that of the fetus. For the woman in this situation, the emotions usually

Karin Jordan, MD
Latest Article

Chemotherapy-Induced Nausea and Vomiting: Great Achievements but Room for Improvement

A review of "Chemotherapy-Induced Nausea and Vomiting: Which Antiemetic for Which Therapy?"

Karl D. Lewis, MD
Latest Article

Metastatic Malignant Melanoma From an Unknown Primary Presenting as a Large Axillary Mass

The patient is an otherwise healthy male transferred from an outside hospital with a newly diagnosed melanoma from an unknown primary presenting as a large, left axillary mass.

Karl G. Blume, MD
Latest Article

Hematopoietic Cell Transplantation, Second Edition

Hematopoietic Cell Transplantation, edited by Drs. Thomas, Blume, and Forman, is an excellent updated second edition of their comprehensive textbook designed for both practitioners involved in transplantation and those interested in the science of stem-cell transplantation.

Karl Glastad, MD
Latest Article

Diagnostic Evaluation of Hepatocellular Carcinoma in a Cirrhotic Liver

Hepatocellular carcinoma (HCC) is one of the world’s most common cancers. It is closely associated with cirrhosis, especially that due to viral hepatitis. The incidences of viral hepatitis and HCC are rising steadily in the United

Karl Lewis, MD
Latest Article

The Absent-Minded Professor: An Unusual Complication of Melanoma

The University of Colorado Health Sciences Center holds weekly second opinion conferences focusing on cancer cases that represent most major cancer sites. Patients seen for second opinions are evaluated by an oncologist.

Karla Kerlikowske, MD
Latest Article

Should We Recommend Screening Mammography for Women Aged 40 to 49?

In clinical trials, screening mammography has been shown to reduce mortality from breast cancer by about 25% to 30% among women aged 50 years and older after only 5 to 6 years from the initiation of screening. Among women 40 to 49 years old, the evidence supporting the efficacy of screening mammography is less convincing.

Karolyn Kerr, MD
Latest Article

Integrated PET-CT: Evidence-Based Review of Oncology Indications

Combined-modality positronemissiontomography (PET)–computed tomography (CT) isbecoming the imaging method ofchoice for an increasing number ofoncology indications. The goal of thispaper is to review the evidence-basedliterature justifying PET-CT fusion.The best evidence comes from prospectivestudies of integrated PETCTscans compared to other methodsof acquiring images, with histopathologicconfirmation of disease presenceor absence. Unfortunately, veryfew studies provide this kind of data.Retrospective studies with similarcomparisons can be used to provideevidence favoring the use of integratedPET-CT scans in specific clinicalsituations. Also, inferential conclusionscan be drawn from studies whereclinical rather than pathologic dataare used to establish disease presenceor absence.

Karthik Ghosh, MD
Latest Article

Commentary (Ghosh et al): Advising Women at High Risk of Breast Cancer

Dr. Wood has provided an excellentreview of the issuesfacing women at high risk fordeveloping breast cancer. In additionto emphasizing the significance of accuraterisk assessment, he describessurveillance techniques that enableearly detection of the disease and hasprovided a comprehensive review ofrisk-reduction options for women athigh risk.

Kasmintan Schrader, MD
Latest Article

Genetic Testing in Gastrointestinal Cancers: A Case-Based Approach

In this article, we use a case-based approach to focus on the hereditary aspects of the most common GI cancers, including pancreatic, gastric, and colon cancer.

Kassa Ayalew, MD
Latest Article

Romiplostim for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura

On August 22, 2008, the US Food and Drug Administration (FDA) granted marketing approval (licensure) to romiplostim (Nplate, Amgen Inc) for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy.

Katarzyna Finiewicz, MD
Latest Article

Management of Infections in Patients With Acute Leukemia

Improvements in outcome following treatment for acute leukemia have derived from various sources: the introduction of new chemotherapeutic agents; the development of effective drug combinations; the use of multistage approaches to induction consolidation, and maintenance therapy to optimize durable control; and advances in supportive care to reduce treatment-related mortality. Certainly, infectious morbidity and mortality have plagued effective antileukemic therapy for many years. As a result, control of infectious complications has been an important area of clinical study. Through the concerted efforts of many clinical investigators, progress has occurred, and, today, infectious mortality is an infrequent complication of antileukemic therapy.

Kate E. Oliver, MD
Latest Article

Venous Thromboembolism in a Gynecologic Cancer Patient

Mrs. S. is a 37-year-old Caucasian female who sought care at her home institution overseas during a period of several months for complaints of esophageal reflux, constipation, early satiety, increasing abdominal girth, and fatigue.

Katherine A. Hammerhofer, RN
Latest Article

Role of Laparoscopic Techniques in Colorectal Cancer Surgery

Laparoscopic intestinal resection is a relatively new application of endoscopic technology that has evolved as a direct result of the successes and benefits seen with laparoscopic gallbladder surgery. Currently acceptable and

Katherine A. Harrison, MD
Latest Article

Diagnostic Use of Radiolabeled Antibodies for Cancer

Antibodies against a variety of tumor-associated antigens have been studied, as well as a number of modifications to the antibodies themselves, including Fab' fragments and chimeric, humanized, and human

Katherine A. Schneider, MPH
Latest Article

Role of the Genetic Counselor in Familial Cancer

The authors offer a comprehensive overview of familial cancer risk counseling, providing both a general definition of this new genetic counseling specialty and specific components of the counseling process. Genetic counseling is, by and large, a referral service, and this is also true of cancer risk counseling. This places great importance on the health-care provider's ability to recognize families who may be at increased risk for an inherited form of cancer and should be referred for cancer risk counseling. It seems reasonable, therefore, to consider the issues relevant to making such a referral, including information on collecting an initial cancer history, strategies for handling a positive history, and the realities of DNA-based testing.

Katherine H. Tkaczuk, MD
Latest Article

A Phase I Study of Paclitaxel, UFT, and Leucovorin

This phase I study examines the dose escalation of UFT given in combination with fixed doses of oral leucovorin and weekly doses of paclitaxel in patients with metastatic solid tumor malignancies (excluding colorectal cancer). There are two main objectives for this study.

Katherine K. Matthay, MD
Latest Article

Neuroblastoma: Biology and Therapy

Neuroblastoma is the most common extracranial solid tumor of childhood, accounting for 15% of cancer-related deaths. These tumors have a predilection for young children; 60% of cases occur before age 2 years and 97%

Katherine M. W. Pisters, MD
Latest Article

Commentary (Pisters): Adjuvant Chemotherapy for Resected Non–Small-Cell Lung Cancer

In this issue of ONCOLOGY, Solomon,Mitchell, and Bunn providean excellent review on adjuvanttherapy for resected non–smallcelllung cancer (NSCLC). Theauthors have thoroughly reviewed therecent literature and highlight severalimportant areas for discussion. Theauthors appropriately frame the importanceof the clinical issue at hand.

Katherine McDermott Blackburn, RN, MPA, OCN
Latest Article

Roles of Advanced Practice Nurses in Oncology

Managed care is a process of health-care management that integrates financing, cost-containment strategies, and business principles with the delivery of health care. Managed care’s rapid transformation of specialty practices,

Katherine O’Brien
Latest Article

You Never Forget Your First Radiologist

The radiologist could not have known exactly what was in store for me, but it obviously wasn’t good. Couldn’t he have dredged up even a nanoparticle of empathy

Katherine Van Loon, MD, MPH
Latest Article

Biomarkers in Colon Cancer: The Chasm Between Expectations and Reality

At this juncture, various commercially available assays for colon cancer may be of little added value, and accelerated biomarker development with clinical validation is desperately needed.