Colorectal Cancer

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Although trilaciclib appears to reduce neutropenia in patients treated with FOLFOXIRI and bevacizumab in patients with metastatic colorectal cancer, the phase 3 PRESERVE 1 trial will be stopped due to a lack of responses.
Trilaciclib Reduces Neutropenia but Fails to Improve ORR in Metastatic CRC

February 13th 2023

Although trilaciclib appears to reduce neutropenia following treatment with FOLFOXIRI and bevacizumab in patients with metastatic colorectal cancer, the phase 3 PRESERVE 1 trial will be stopped due to a lack of responses.

Recap: Review of Molecular Testing Options in Metastatic Colorectal Cancer
Recap: Review of Molecular Testing Options in Metastatic Colorectal Cancer

February 4th 2023

Findings from the phase 3 BREAKWATER study indicate that encorafenib plus cetuximab and chemotherapy produces activity and is well-tolerated in metastatic colorectal cancer harboring BRAF V600E mutations.
Encorafenib Combo Yields Promising Activity in BRAF V600E-Mutant mCRC

January 24th 2023

Findings from the phase 2 MOUNTAINEER trial indicate that HER2 scoring algorithms may help in identifying which patients are suitable to receive tucatinib plus trastuzumab for metastatic colorectal cancer.
Scoring Algorithms Demonstrate Utility in Screening for Optimal Treatment for HER2+ mCRC

January 23rd 2023

Findings from the phase 3 SUNLIGHT study highlight favorable overall survival and disease control rates with the use of bevacizumab plus trifluridine and tipiracil in metastatic colorectal cancer.
Bevacizumab Combo Yields Survival, DCR Benefits in mCRC

January 23rd 2023

Video Series
Video Interviews
Podcasts
Lead author Ibrahim Halil Sahin, MD, spoke with CancerNetwork® about his work investigating postoperative circulating tumor DNA dynamics in early-stage colon cancer as part of the CIRCULATE-US trial published in the journal ONCOLOGY®.
Between the Lines™ Podcast: ctDNA as a Biomarker of Progression in Colorectal Cancer
Oncology Peer Review On-The-Go
Oncology Peer Review On-The-Go

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