April 18th 2024
The FDA has approved alectinib for the adjuvant treatment of patients with ALK-positive non-small cell lung cancer with tumors that are least 4 cm or node positive, as detected by an FDA-approved test.
Breaking Down Biomarkers in Non–Small Cell Lung Cancer: A Case-Based Discussion for the Oncology Nurse
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Go To PER in Chicago
May 31, 2024 - June 2, 2024
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The Top 10 Oncogenic Drivers in NSCLC for 2023: What You Need to Know on Tumor Testing, Targets, and Treatment Strategies to Move the Field Forward
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Expanding the Armamentarium of Actionable Mutations in NSCLC: Uncovering the Potential of CEACAM5 as a Therapeutic Target
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Pathology Implications for CEACAM5 as a Therapeutic Target in Advanced NSCLC
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Medical Crossfire®: What Are Effective Strategies for Onco-Nurses to Improve Outcomes in Patients with Small Cell Lung Cancer?
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Virtual Show Me the Data™: How HER2, HER3, and TROP2 Targeted Strategies Will Impact Evolving Paradigms in NSCLC
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42nd Annual CFS®: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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How CEACAM5 Expression Can Be Measured and Leveraged in NSCLC Care: Current Developments & Future Therapeutic Opportunities
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Medical Crossfire®: Where Are We in the World of ADCs? From HER2 to CEACAM5, TROP2, HER3, CDH6, B7H3, c-MET and Beyond!
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Community Oncology Connections™: Overcoming Barriers to Testing, Trial Access, and Equitable Care in Cancer
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22nd Annual Winter Lung Cancer Conference®
January 31, 2025 - February 2, 2025
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Dialogues With the Surgeon on Integration of Systemic Therapies in Perioperative Settings for NSCLC: Looking at EGFR, ALK, IO, and Beyond…
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California’s Lung Cancer Decline Shows Effectiveness of Tobacco Control
January 1st 2001WASHINGTON-California’s aggressive tobacco control efforts, which include raising tobacco taxes and using some of that revenue for prevention efforts, appear to have played a significant role in the state’s decrease in lung cancer rates, according to a new collaborative study released by the Centers for Disease Control and Prevention and the California Department of Health Services.
Lung Cancer Screening With 1 mm Multislice CT Scans
January 1st 2001NEW YORK-Thinner multislice CT scans are increasing the effectiveness of lung cancer screening, a German investigator said at the 3rd International Conference on Screening for Lung Cancer. U. Joseph Schoepf, MD, of the Institute of Clinical Radiology, University of Munich, showed images from 1 mm slices achieved with the Siemens Volume Zoom. "Obviously, we use the fastest rotation mode that we have available," he said. "That’s a 500 millisecond rotation. With a collimation of 1 mm, that allows us to cover the entire chest in a single breath-hold of about 20 to 25 seconds."
Current Status of Irinotecan in Lung Cancer
January 1st 2001Survival in lung cancer patients has not improved over the past 2 decades. Irinotecan (Camptosar, CPT-11), a semisynthetic analog of the quinoline-based alkaloid camptothecin, is one of several new drugs that have demonstrated promising activity in the treatment of lung cancer in recent years. This article gives a brief overview of the mechanism, development history, and current uses of this agent. [ONCOLOGY 15(Suppl 1):6-7, 2001]
Establishment of the Standard Regimen for Non-Small- Cell Lung Cancer in Japan
January 1st 2001Preclinical data suggest that irinotecan (Camptosar, CPT-11), a novel topoisomerase I inhibitor, has exhibited promising activity in the treatment of lung cancer. In a phase II study of non-small-cell lung cancer, irinotecan
Irinotecan in Combined-Modality Therapy for Locally Advanced Non-Small-Cell Lung Cancer
January 1st 2001The management of non-small-cell lung cancer is undergoing rapid evolution. Although the advent of combined-modality therapy has led to improved survival, most patients eventually succumb to the disease. The arrival of a
Treatment of Non-Small-Cell Lung Cancer in North America: The Emerging Role of Irinotecan
January 1st 2001Topoisomerase I inhibitors have demonstrated significant activity in non-small-cell lung cancer. In phase II studies, particularly in Japan, single-agent irinotecan (Camptosar, CPT-11) has produced response rates as high
Antifolate + Platinum in Advanced NSCLC
December 1st 2000TOKYO-A platinum-based regimen including the investigational antifolate pemetrexed disodium (Alimta) is active and well tolerated in stage IIIb/IV non-small cell lung cancer (NSCLC), according to the final results of a phase II trial conducted by the National Cancer Institute of Canada Clinical Trials Group and presented at the 9th World Conference on Lung Cancer. The drug may also represent a new option for patients with mesothelioma.
National Cancer Institute Launches Lung Screening Study
December 1st 2000The National Cancer Institute (NCI) is recruiting 3,000 current and former smokers for its Lung Screening Study, a year-long study of spiral computed tomography (CT) scans for lung cancer screening. Although the study will not determine if the
Vinorelbine/Cisplatin Effective in Metastatic NSCLC
December 1st 2000HAMBURG, Germany-GLOB-1 trial results, reported at the 25th Congress of the European Society of Medical Oncology (ESMO), have confirmed the combination of vinorelbine (Navelbine) and cisplatin (Platinol) as a chemotherapy reference standard in metastatic non-small-cell lung cancer (NSCLC), raising questions about the role of three-drug combinations in this setting.
Nonplatinum Regimen Appears Active in Advanced NSCLC
December 1st 2000TOKYO-A regimen of paclitaxel (Taxol) and vinorelbine (Navelbine) in non-small-cell lung cancer (NSCLC) appears to yield results similar to those with platinum-based regimens, according to phase I/II studies presented at the 9th World Conference on Lung Cancer.
Neoadjuvant Docetaxel May Increase Survival in Locally Advanced NSCLC
December 1st 2000TOKYO-Neoadjuvant therapy with the taxane docetaxel (Taxotere) is well tolerated and boosts survival over local treatment alone in patients with radically treatable, locally advanced non-small-cell lung cancer (NSCLC), investigators reported at the Ninth World Conference on Lung Cancer.
Pharmacology of Antineoplastic Agents in Older Cancer Patients
December 1st 2000The fastest growing segment of the US population is the group over the age of 65 years. In the next 30 years, this group will comprise over 20% of the population. Because 60% of all cancers occur in this age group, there will be an expected rise in the total cancer burden.
Cisplatin/Irinotecan Offers Survival Advantage in Stage IV Non–Small-Cell Lung Cancer
November 1st 2000OSAKA, Japan-Patients with stage IV non–small-cell lung cancer randomized to a regimen of cisplatin (Platinol) and irinotecan (Camptosar) survived significantly longer than those receiving a cisplatin/vindesine combination in a phase III trial conducted in Japan.
Irinotecan/Etoposide Combination Achieves 65% Overall Response Rate
November 1st 2000OSAKA, Japan-An overall response rate of 66% was achieved with a combination of irinotecan (Camptosar) and etoposide (VePesid) in patients with advanced small-cell lung cancer in a phase II study performed by the West Japan Thoracic Oncology Group. A final report on the study, conducted from 1995-98, was presented by Shinzoh Kudoh, MD, of Osaka City University School of Medicine.
Doses Determined for Phase II Study of Irinotecan/Cisplatin with Concurrent Radiation
November 1st 2000NAGASAKI, Japan-The combination of irinotecan (Camptosar) 40 mg/m² and cisplatin (Platinol) 60 mg/m² with concurrent thoracic radiotherapy should be tested for its potential role in treating patients with limited-stage small-cell lung cancer (SCLC).The recommendation was made at the conclusion of a phase I trial that evaluated the combination of irinotecan and cisplatin in three dose schedules in patients with histologically or cytologically proven limited-stage SCLC who had not undergone prior therapy for their disease.
PET Scans Predict Survival in Non-Small-Cell Lung Cancer Patients
November 1st 2000NEW ORLEANS-Positron emission tomography (PET) scanning is a powerful predictor of survival in patients with non-small-cell lung cancer (NSCLC), reported Michael MacManus, MD, of the Peter MacCallum Cancer Institute, East Melbourne, Australia.
Search for More Satisfactory Therapy Leads to Gemcitabine/Mitomycin-C Combination
November 1st 2000HAMBURG, Germany-“The overall results of the treatment of advanced non–small-cell lung cancer are unsatisfactory,” Ulrich Gatzemeier, MD, said in an overview of recent German trials he presented at the 9th World Conference on Lung Cancer. Dr. Gatzemeier is head of the Department of Thoracic Oncology with Hospital Grosshansdorf, Hamburg, Germany.
Irinotecan May Be One of the Most Active Agents Available Against Extensive Small-Cell Lung Cancer
November 1st 2000TOKYO, Japan-New phase III trial data suggest that irinotecan is one of the most active agents available to treat extensive-disease small-cell lung cancer, outperforming the standard etoposide (VePesid)/cisplatin (Platinol) treatment, while causing less myelosuppression.
Eight SCLC Patients Receiving Paclitaxel/Cisplatin/Etoposide Combination Die
November 1st 2000HERAKLION, Greece-A multicenter phase III study comparing the triple combination of paclitaxel (Taxol), cisplatin (Platinol), and etoposide (VePesid) to the double combination of cisplatin and etoposide as front-line treatment for small-cell lung cancer was stopped because of eight toxic deaths. Less than a third of the planned number of patients had been accrued.
Optimal Topotecan Sequence and Combination in First-Line SCLC Treatment Elusive
November 1st 2000MADISON, Wisconsin-Although topotecan (Hycamtin) has clear activity in small-cell lung cancer, the optimal combinations, schedule, and route of administration for use of this topoisomerase-I inhibitor as first-line therapy are yet to be determined, according to Joan H. Schiller, MD, of the University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin.
Irinotecan Highly Active in Lung Cancer
November 1st 2000TOKYO, Japan-“I remain convinced that irinotecan is one of the most active agents for the treatment of lung cancer, both non–small-cell and small-cell,” stated David H. Johnson, MD, professor of medicine and director of medical oncology at Vanderbilt University Medical Center, Nashville. Dr. Johnson was leadoff speaker at a seminar titled ‘‘Current Status of Irinotecan in Lung Cancer’’ held in conjunction with the 9th World Conference on Lung Cancer. The meeting was supported by an educational grant from Pharmacia Oncology, Yakult Honsha Co., Ltd., Daiichi Pharmaceutical Co., Ltd., and Aventis Pharma S.A.
Novel Treatment Option in Older Patients With Relapsed Lung Cancer: Weekly Docetaxel
November 1st 2000Weekly dosing of the chemotherapy agent docetaxel (Taxotere) is active and well tolerated in elderly patients with advanced non–small-cell lung cancer (NSCLC), according to the results of a phase II study published in a recent issue of Cancer (89[2]:328-333, 2000).
Irinotecan/Docetaxel Combination Has Potential in Recurrent Non–Small-Cell Lung Cancer
November 1st 2000ROCHESTER, Minnesota-The combination of irinotecan (Camptosar)and docetaxel (Taxotere) is a promising treatment for recurrent non–small-cell lung cancer (NSCLC), but the dosing schedule tested in phase I and II trials needs to be modified to reduce the potential for myelosuppression and diarrhea, cautioned Alex Adjei, MD, of the Mayo Clinic in Rochester, Minnesota.
ECOG Seeks New Agents to Make Greater Headway Against Advanced Non–Small-Cell Lung Cancer
November 1st 2000NASHVILLE, Tennessee-Conceding that treatment of advanced non–small-cell lung cancer (NSCLC) has made only limited progress in the past decade, members of the Eastern Cooperative Oncology Group (ECOG) have vowed to pursue newer chemotherapeutic agents aggressively. ECOG’s focus has changed, according to David H. Johnson, MD, director of hematology and oncology with the Vanderbilt-Ingram Cancer Center, Nashville. Investigators now see the promise in new biological agents with novel mechanisms of action that might be integrated into current chemotherapeutic regimens.