April 18th 2024
The FDA has approved alectinib for the adjuvant treatment of patients with ALK-positive non-small cell lung cancer with tumors that are least 4 cm or node positive, as detected by an FDA-approved test.
Breaking Down Biomarkers in Non–Small Cell Lung Cancer: A Case-Based Discussion for the Oncology Nurse
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Go To PER in Chicago
May 31, 2024 - June 2, 2024
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The Top 10 Oncogenic Drivers in NSCLC for 2023: What You Need to Know on Tumor Testing, Targets, and Treatment Strategies to Move the Field Forward
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Expanding the Armamentarium of Actionable Mutations in NSCLC: Uncovering the Potential of CEACAM5 as a Therapeutic Target
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Pathology Implications for CEACAM5 as a Therapeutic Target in Advanced NSCLC
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Medical Crossfire®: What Are Effective Strategies for Onco-Nurses to Improve Outcomes in Patients with Small Cell Lung Cancer?
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Virtual Show Me the Data™: How HER2, HER3, and TROP2 Targeted Strategies Will Impact Evolving Paradigms in NSCLC
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42nd Annual CFS®: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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How CEACAM5 Expression Can Be Measured and Leveraged in NSCLC Care: Current Developments & Future Therapeutic Opportunities
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Medical Crossfire®: Where Are We in the World of ADCs? From HER2 to CEACAM5, TROP2, HER3, CDH6, B7H3, c-MET and Beyond!
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Community Oncology Connections™: Overcoming Barriers to Testing, Trial Access, and Equitable Care in Cancer
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22nd Annual Winter Lung Cancer Conference®
January 31, 2025 - February 2, 2025
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Dialogues With the Surgeon on Integration of Systemic Therapies in Perioperative Settings for NSCLC: Looking at EGFR, ALK, IO, and Beyond…
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Non–Small-Cell Lung Cancer Single-Agent Therapy
August 2nd 2000The objective of this study was to determine the effects of docetaxel (Taxotere) on survival, clinical benefits, quality of life, and safety parameters for chemonaive patients with advanced non–small-cell lung cancer (NSCLC), when compared to best supportive care (BSC) (no chemotherapy or systemic anticancer therapy permitted).
New Agents in Combination Regimens
August 2nd 2000Designated E1594, this trial was designed to compare three platinum-based combination regimens containing third-generation drugs active against non–small-cell lung cancer to a reference regimen of cisplatin (Platinol) 75 mg/m² day 1 plus paclitaxel (Taxol) 175/mg/m²/24 h (arm A). The experimental regimens were as follows: gemcitabine (Gemzar) 1,000 mg/m² days 1, 8, 15 plus cisplatin 100 mg/m² day 1 (arm B); docetaxel (Taxotere) 75 mg/m² day 1 plus cisplatin 75 mg/m² day 1 (arm C); and paclitaxel 225 mg/m²/3 h day 1 plus carboplatin (Paraplatin) at an area under the concentration-time curve of 6 (AUC in mg/mL · min) day 1 (arm D). Arms A, C, and D were repeated every 21 days and arm B every 28 days.
We previously reported the efficacy of concurrent cisplatin (Platinol)/etoposide (PE) and radiotherapy in stage IIIB non–small-cell lung cancer in which biopsy confirmation of T4 (noneffusion) or N3 status was required (S9019). In view of the activity of docetaxel (Taxotere) as second-line therapy and potential molecular mechanisms of action favoring taxane sequencing, we designed the present study to maintain a core of concurrent PE/radiotherapy, but to substitute docetaxel consolidation for the two additional cycles of PE.
Irinotecan Plus Cisplatin May Be a Promising Radiation Sensitizer, According to Phase II Study
August 1st 2000OSAKA, Japan-Induction with irinotecan (Camptosar) and cisplatin (Platinol) followed by thoracic radiation combined with weekly irinotecan in patients with unresectable non–small-cell lung cancer (NSCLC) seems to be a feasible regimen in a cooperative group setting, according to the preliminary results of a phase II study presented in an ASCO abstract.
Major Trial of Four Newest Chemotherapy Regimens for Advanced NSCLC Shows Comparable Survival
August 1st 2000MADISON, Wis-The first major trial to compare three of the newest chemotherapy regimens for advanced non–small-cell lung cancer (NSCLC) with the most commonly used combination found that all offered similar survival benefits.
Interim Results Show Similar Response Rates for TEC vs CEV in Small-Cell Lung Cancer
August 1st 2000GROSSHANSDORF, Germany-Initial efficacy results of a randomized phase III trial of previously untreated small-cell lung cancer (SCLC) show that paclitaxel (Taxol)/etoposide/carboplatin (TEC) and carboplatin/etoposide/vincristine (CEV) are both well tolerated with similar response rates. The findings were presented at the 36th Annual Meeting of the American Society of Clinical Oncology (ASCO).
Brain Metastases Respond to Paclitaxel, Carboplatin, and Brain RT
August 1st 2000NEW ORLEANS-In patients with brain metastases related to non-small-cell lung cancer, adding paclitaxel (Taxol) plus carboplatin (Paraplatin) to standard radiotherapy may increase overall treatment efficacy, French investigators reported at the 36th Annual Meeting of the American Society of Clinical Oncology.
Gemcitabine/Vinorelbine Boosts Survival in Elderly NSCLC Patients
August 1st 2000NEW ORLEANS-In elderly non-small-cell lung cancer (NSCLC) patients, the combination of gemcitabine (Gem-zar) plus vinorelbine (Navelbine) yields better survival than vinorelbine alone, according to the final analysis of a Southern Italy Cooperative Oncology Group (SICOG) phase III trial. Giuseppe Frasci, MD, of the National Tumor Institute, Naples, Italy, reported the results at the 36th Annual Meeting of the American Society of Clinical Oncology (ASCO).
High Toxic Death Rate Closes Paclitaxel Plus EP Study Early
August 1st 2000HERAKLION, Greece-A multicenter randomized phase III study comparing paclitaxel (Taxol)/etoposide/cisplatin (Platinol) (TEP) with standard-therapy etoposide/cisplatin (EP) in patients with small-cell lung cancer (SCLC) was stopped prematurely due to a 13% toxic death rate, according to a report given at the 36th Annual Meeting of the American Society of Clinical Oncology (ASCO).
CT Screening for Lung Cancer Will Save Lives and Money Researcher Claims
August 1st 2000NEW YORK-A new screening procedure to detect early lung cancer has the potential to dramatically reduce mortality, Claudia Henschke, MD, PhD, chief, Division of Chest Imaging, Weill Medical College of Cornell University, said at a media briefing.
Landmark Study Shows Chemotherapy Improves Survival in Late-Stage Lung Cancer Patients
August 1st 2000A landmark research trial by the University of Wisconsin Comprehensive Cancer Center showed that chemotherapy offers survival benefits for advanced, non–small-cell lung cancer patients. The study, presented at the 36th annual meeting of the
Survival Benefit Seen With Irinotecan/Cisplatin in Metastatic Non–Small-Cell Lung Cancer
August 1st 2000OSAKASAYAMA, Japan-Irinotecan (Camptosar) plus cisplatin (Platinol) significantly improves survival, compared to vindesine/cisplatin, in patients with metastatic non–small-cell lung cancer (NSCLC), according to an analysis of two studies presented by Masahiro Fukuoka, MD, of Kinki University School of Medicine, Osakasayama, Japan, at a poster session at the American Society of Clinical Oncology (ASCO) annual meeting
Advanced Age Usually Not a Factor in Platinum-Based Therapy for NSCLC
August 1st 2000PHILADELPHIA-Fit, elderly patients with non–small-cell lung cancer (NSCLC) can handle platinum-based therapy as well as younger patients, according to a secondary analysis of data from Eastern Cooperative Oncology Group (ECOG) study 5592. Corey Langer, MD, of Fox Chase Cancer Center, presented the analysis at the ASCO annual meeting.
Cigar Companies Agree to Health Warnings on Products and Ads
August 1st 2000WASHINGTON-The seven largest US cigar companies will place health warnings on their products and advertisements as the result of an agreement with the US Federal Trade Commission. The warnings read: “Cigar smoking can cause cancers of the mouth and throat, even if you do not inhale.” “Cigar smoking can cause lung cancer and heart disease.” “Tobacco use increases the risk of infertility, stillbirth, and low birth weight.” “Cigars are not a safe alternative to cigarettes.” “Tobacco smoke increases the risk of lung cancer and heart disease, even in nonsmokers.”
Gemcitabine Plus Vinorelbine Offers Better Survival Than Vinorelbine Alone in Elderly NSCLC Patients
August 1st 2000NAPLES, Italy-In elderly non-small-cell lung cancer (NSCLC) patients, gemcitabine (Gemzar) combined with vinorelbine (Navelbine) was associated with significantly better survival in comparison to treatment with vinorelbine alone, Giuseppe Frasci, MD, reported at the 36th ASCO Annual Meeting.
Etoposide/Carboplatin/Paclitaxel Effective in Extensive SCLC
August 1st 2000NEW ORLEANS-The addition of paclitaxel (Taxol) to a regimen of etoposide and carboplatin (Paraplatin) led to a modest improvement in response rate and a trend toward improved survival in patients with small-cell lung cancer (SCLC), investigators from Response Oncology Inc., Memphis, Tennessee, reported at the 36th Annual Meeting of the American Society of Clinical Oncology (ASCO).
Docetaxel Plus Irinotecan Promising as Nonplatinum Regimen for Advanced Non–Small-Cell Lung Cancer
August 1st 2000OSAKA, Japan-Docetaxel (Taxotere) plus irinotecan (Camptosar) seems to have activity comparable to docetaxel plus cisplatin (Platinol) in advanced non–small-cell lung cancer (NSCLC), according to the results of a randomized phase II study reported at ASCO.
Evolution of Combined Modality Therapy for Stage III Non–Small-Cell Lung Cancer
A number of randomized clinical trials and meta-analyses now support the conclusion that combined modality regimens that include cisplatin (Platinol)-based chemotherapy improve survival in stage III non–small-cell lung
Phase I/II Trial of Irinotecan, Carboplatin, and Paclitaxel in Advanced or Metastatic NSCLC
This multicenter study enrolled 73 patients with locally advanced or metastatic non–small-cell lung cancer (NSCLC). The study design was based on the hypothesis that the non-overlapping toxicities of a 3-drug