ONCOLOGY Vol 15 No 7 | Oncology

Bush Administration Considering Physician Ratings

July 01, 2001

Thomas Scully, the new administrator of the Health Care Financing Administration, is moving fast to make improvements to Medicare. A proposal to collect and publish quality and outcome information on health-care practitioners who treat

Prostate Cancer and Spinal Cord Compression

July 01, 2001

Metastatic spinal disease is common in patients with prostate cancer. Spinal metastases may be asymptomatic (identified during staging) or cause pain and other neurologic signs and symptoms. In approximately 30% of prostate cancer patients,

Current Status of Thalidomide in the Treatment of Cancer

July 01, 2001

In his comprehensive review, Dr. Rajkumar provides a summary of the current status of thalidomide (Thalomid) therapy in cancer. As discussed in the article, it was the teratogenic effects, particularly phocomelia, that prompted researchers to

Risk of Breast and Ovarian Cancer in Women With Strong Family Histories

July 01, 2001

Assessing the risk of breast and ovarian cancer starts with obtaining a complete and accurate family history. This can reveal evidence of inherited cancer risk. The highest risk of cancer is associated with germ-line abnormalities

Risk of Breast and Ovarian Cancer in Women With Strong Family Histories

July 01, 2001

Assessing the risk of breast and ovarian cancer starts with obtaining a complete and accurate family history. This can reveal evidence of inherited cancer risk. The highest risk of cancer is associated with germ-line abnormalities

Current Status of Thalidomide in the Treatment of Cancer

July 01, 2001

Dr. Rajkumar has written an excellent overview of the current status of thalidomide (Thalomid) in the treatment of cancer. There is a constant demand for novel therapeutic strategies as alternative or complementary options to the existing armamentarium of chemotherapeutic agents for various malignant disorders.

Risk of Breast and Ovarian Cancer in Women With Strong Family Histories

July 01, 2001

Assessing the risk of breast and ovarian cancer starts with obtaining a complete and accurate family history. This can reveal evidence of inherited cancer risk. The highest risk of cancer is associated with germ-line abnormalities

Prostate Cancer and Spinal Cord Compression

July 01, 2001

Metastatic spinal disease is common in patients with prostate cancer. Spinal metastases may be asymptomatic (identified during staging) or cause pain and other neurologic signs and symptoms. In approximately 30% of prostate cancer patients,

Pancreatic Cancer in the Older Patient

July 01, 2001

Pancreatic cancer is a disease seen predominantly in elderly patients. Compared to younger patients, older patients are more likely to present with early-stage disease and, therefore, may be candidates for aggressive local

Commentary (Niederhuber): Pancreatic Cancer in the Older Patient

July 01, 2001

Pancreatic cancer is a disease seen predominantly in elderly patients. Compared to younger patients, older patients are more likely to present with early-stage disease and, therefore, may be candidates for aggressive local

The Emerging World Role of Irinotecan in Lung Cancer

July 01, 2001

Irinotecan (CPT-11, Camptosar), either alone or in combination with cisplatin (Platinol), has demonstrated activity in advanced non-small-cell lung cancer (NSCLC). In single-agent studies, response rates as high as 35%

Current Status of Thalidomide in the Treatment of Cancer

July 01, 2001

Tumor angiogenesis is a critical factor in the growth and metastasis of most malignant neoplasms. Thalidomide (Thalomid), banned from clinical use in the 1960s because of severe teratogenicity, has been shown to possess

Risk of Breast and Ovarian Cancer in Women With Strong Family Histories

July 01, 2001

Assessing the risk of breast and ovarian cancer starts with obtaining a complete and accurate family history. This can reveal evidence of inherited cancer risk. The highest risk of cancer is associated with germ-line abnormalities

Role of Topoisomerase I Inhibitors in Small-Cell Lung Cancer

July 01, 2001

Combination chemotherapy is the cornerstone of treatment that confers a meaningful survival benefit for patients with small-cell lung cancer. However, because there have been no major therapeutic advances for small-cell lung

Irinotecan in Relapsed or Refractory Non-Hodgkin’s Lymphoma

July 01, 2001

Irinotecan (CPT-11, Camptosar) is a topoisomerase I inhibitor with a broad spectrum of antitumor clinical activity. Various schedules and doses have been studied, and major complications were delayed diarrhea and

Prostate Cancer and Spinal Cord Compression

July 01, 2001

Prostate cancer metastasis to the spine is an extremely difficult clinical problem to treat. However, it occurs commonly, and all clinicians-not only oncologists-should undertake to understand its pathogenesis, diagnosis,

Current Clinical Trials With STI571

July 01, 2001

STI571 (Gleevec) is a member of the 2-phenylaminopyrimidine family of adenosine triphosphate (ATP) binding site inhibitors of protein tyrosine kinase. It potently inhibits the tyrosine kinase activity of Abl and Bcr-Abl,[1-3] platelet-derived growth factor receptor (PDGF-R), and Kit (stem cell factor receptor).[4-6]

Commentary (Brand et al): Pancreatic Cancer in the Older Patient

July 01, 2001

Pancreatic cancer is a disease seen predominantly in elderly patients. Compared to younger patients, older patients are more likely to present with early-stage disease and, therefore, may be candidates for aggressive local