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SANTA MONICA, California-Vascular endothelial growth factor (VEGF) offers a number of sites for therapeutic targeting and is thought to play an important role in human cancers. Several angiogenesis inhibitors that work through effects on VEGF are under development, but one that failed in a phase III study may offer important insights for investigators developing this new area of anticancer therapy according to Lee S. Rosen, MD. Dr. Rosen, who was involved in research on the tyrosine kinase inhibitor SU5416, is director of developmental therapeutics, Cancer Institute Medical Group, Santa Monica, California.

PORTLAND, Oregon-Median survival for patients with advanced colorectal cancer treated with front-line regimens that include irinotecan (CPT-11,Camptosar) or oxaliplatin (Eloxatin) is approaching 3 years. "That is an absolutely remarkable figure to me," said Charles D. Blanke, MD, in a review of new approaches to colorectal cancer treatment. Dr. Blanke is director of the gastrointestinal malignancies program at the Oregon Health Sciences University Cancer Institute in Portland.

For several decades, the nutritional deterioration ofpatients diagnosed with cancer has been recognized,and attempts have been made to prevent orreverse it. However, with all the advancements intechnology and medicine, it is somewhat surprisingto find that little has altered in the approach or themanagement of cancer patients suffering from acompromised nutritional status or altered metabolismdue to either the treatment or the disease process.

As Dr. Raghavan has emphasizedin his excellent overviewof the current therapyfor testis cancer, it is critical that thesuccess of therapy for this diseasenot be compromised by a desire toavoid the complications of therapy.We would wholeheartedly agree withhis assertion that modifications intherapy must be introduced with athoughtful and structured approachto minimize the risk to efficacy.

The Department of Health and Human Services (HHS) has createda unified advisory committee on human immunodeficiency virus(HIV) and sexually transmitted diseases (STD) by merging twoexisting groups. The new committee brings together the AdvisoryCommittee for HIV Prevention at the Centers for Disease Control andPrevention (CDC) and the AIDS Advisory Committee at the HealthResources and Services Administration (HRSA). The two groups havemet jointly on several occasions during the last 2 years, and all currentmembers of the two bodies will serve on the new CDC/HRSA AdvisoryCommittee on HIV and STD Prevention and Treatment.

A6-year prostate cancer research plan released by the NationalInstitutes of Health (NIH) contains a detailed outline of theNational Cancer Institute’s (NCI) future strategy for dealingwith the disease, which includes a shift in the standard treatment modelfrom seek-and-destroy to target-and-control.

In a recent study, Wolfe and others interviewed 103parents of children who had died from cancer.[1]Approximately 80% of these children suffered anorexia,or loss of appetite. Over 35% of parents identifiedanorexia as a cause of distress for their child whena physician failed to recognize it. Wolfe and othersconcluded,"greater attention to symptomcontrol.…might ease…suffering." In adults, the syndromeof cancer anorexia/weight loss is no lesspervasive, and no less distressing. Anorexia is one ofthe most deleterious symptoms, surpassed only bypain and fatigue.[2] The majority of adults withadvanced cancer suffer from it toward the end of life.Among all cancer patients-regardless of age orcancer type-"greater attention to [the anorexia/weightloss syndrome]…might ease…suffering."

The management of germ cell tumors has advanced dramatically,with cure rates approaching 90% to 95%. Treatment of stage I/Aseminomas generally includes orchiectomy and adjuvant radiotherapy.Treatment of stage I/A nonseminomatous germ cell tumors involvesorchiectomy followed by retroperitoneal lymph node dissection oractive surveillance. One of the major advances has been the introductionof cisplatin-based chemotherapy for metastatic disease and thedevelopment of a system of risk attribution. The logical managementof any patient with curable disease is to provide curative therapy andthen follow the patient in a structured manner, to diagnose and treatany complications in a timely manner.

Despite many therapeutic options for chronic lymphocytic leukemia(CLL), the disease remains incurable. Since monoclonal antibodiesand recombinant toxins that bind surface antigens expressed on themalignant lymphocytes have been developed, targeted therapy hasbecome a vital option in treating CLL. Rituximab (Rituxan), a chimerichuman-mouse anti-CD20 antibody, and alemtuzumab (Campath), ahumanized anti-CD52 monoclonal antibody, have both shown activityin CLL-as single agents and in combination with conventionalchemotherapy. The possibility of combining antibodies has beenexplored as well, with some efficacy. In this review, we discuss theclinical data on the activity of commercially available antibodies inCLL, both as monotherapy and in combination with other agents.

Palliative care, previously viewed by many as anend-of-life movement, is now recognized as anapproach whose principles should infuse the care ofall patients with a chronic illness throughout the fullcourse of that illness. For example, the World HealthOrganization (WHO) has redefined palliative care asfollows:

WASHINGTON-The Department of Health and Human Service (HHS) has created a unified advisory committee on HIV and sexually transmitted diseases (STD) by merging two existing groups. The new committee brings together the Advisory Committee for HIV Prevention at the Centers for Disease Control and Prevention (CDC) and the AIDS Advisory Committee at the Health Resources and Services Administration (HRSA). The two groups have met jointly on several occasions during the last 2 years, and all current members of the two bodies will serve on the new CDC/HRSA Advisory Committee on HIV and STD Prevention and Treatment.

BETHESDA, Maryland-Two medical facilities have received the first grants awarded by the National Cancer Institute’s Cooperative Planning Grant for Cancer Disparities Research Partnerships (CDRP). The 5-year, $27 million program provides support for radiation oncology clinical research at institutions that have not traditionally participated in NCI-sponsored studies. The two grants, totaling more than $2.5 million, went to the Rapid City Regional Hospital in South Dakota ($1,404,486), which serves a largely Native American population, and the Mercy Health Center, Laredo, Texas ($1,120,013), which serves a largely Hispanic community.

ORLANDO-A randomized trial found that an implantable drug delivery system (IDDS) was superior to comprehensive medical management (CMM) in reducing pain among cancer patients and a quality of life analysis showed that decreasing pain improved quality of life not only for patients but also for their caregivers.

VANCOUVER-Inex Pharmaceuticals Corporation has announced positive results from a pivotal phase II/III clinical trial evaluating its lead anticancer product Onco TCS (liposomal vincristine) as single-agent therapy for relapsed aggressive non-Hodgkin’s lymphoma. The trial results will form the basis for a New Drug Application seeking approval for marketing from the US Food and Drug Administration (FDA). The 102 study patients had received an average of four other regimens, and 75% had resistant disease. The overall response rate with Onco TCS was 24%, including five complete responses.

ORLANDO-Intratumoral injection of dendritic cells genetically modified to express CD40 ligand (CD40L) eradicated breast tumors in mice, Zoya R. Yurkovetsky, a PhD student from the Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, reported at the Era of Hope Department of Defense Breast Cancer Research Program meeting.

WASHINGTON-The 8-year drive to test pregnant women for HIV as a means of preventing perinatal transmission of the virus had varying degrees of success, according to a new report from the Centers for Disease Control and Prevention (CDC).

BOSTON-A review of more than 1,600 patients in the Oncology Practice Pattern Study found a 50% higher risk of febrile neutropenia for elderly patients than younger patients. Most incidents occurred during the first 21 days of chemotherapy, according to a presented at the third meeting of the International Society of Geriatric Oncology (SIOG abstract P-22). Based on the analysis, Vincent Caggiano, MD, medical director, Sutter Cancer Center, Sacramento, and his colleagues urged oncologists to consider giving prophylactic colony-stimulating factors (CSFs) during the first two chemotherapy cycles-especially among older patients who are more vulnerable to the complication.

SEATTLE-Cigarette smoking appears to be a significant risk factor for colon polyps, equal to a family history of colon cancer, according to Rajeev Attam, MD, a senior fellow in the Division of Gastroenterology, Stony Brook University School of Medicine, New York. In a large colon cancer screening study, approximately 19% of ex-smokers and 17% of nonsmokers had polyps, compared with 25% of current smokers.

BETHESDA, Maryland-With its budget frozen at last year’s level, National Cancer Institute (NCI) officials have cut back on the number of competing research grants awarded during the first 3 months of fiscal year 2003, which began last October 1.

NEW YORK-Dose escalation of irinotecan (Camptosar) is continuing in a phase I trial of a four-drug regimen that has shown encouraging activity in patients with pancreatic and gallbladder cancer, according to a report at the Mount Sinai School of Medicine Chemotherapy Foundation Symposium XX.

NEW YORK-New data suggests that granisetron (Kytril) can effectively prevents postoperative nausea and vomiting at doses as low as 0.1 mg. Robert D’Angelo, MD, Department of Anesthesiology, Wake Forest University, Baptist Medical Center, presented the study results at the 56th Annual Post Graduate Assembly in Anesthesiology.

BETHESDA, Maryland-The National Cancer Institute (NCI) has launched a 5-year, $7.6 million project at seven leading cancer centers to address the disease among Asian Americans. Although Asian Americans have a relatively low overall risk, their cancer incidence is rising faster than that of any other racial or ethnic group in the United States.

NEW ORLEANS-The addition of concurrent cisplatin (Platinol) chemotherapy to radiation therapy after surgery failed to significantly improve locoregional control of high-risk head and neck cancers in the RTOG 9501/Intergroup phase III trial reported at the plenary session of the American Society for Therapeutic Radiology and Oncology (abstract plenary 3).

TARRYTOWN, New York-Aton Pharma, Inc and its collaborators presented phase I data on its oral histone deacetylase inhibitor SAHA (suberoylanilide hydroxamic acid) at the 14th Annual EORTC/NCI/AACR symposium, held in Frankfurt, Germany. The trial of patients with refractory solid tumors, lymphomas, and leukemias, being conducted with researchers at Memorial Sloan-Ket-tering Cancer Center, defined a safe daily oral dosing regimen.

BETHESDA, Maryland-A 6-year prostate cancer research plan released by the National Institutes of Health (NIH) contains a detailed outline of the National Cancer Institute’s (NCI) future strategy for dealing with the disease, which includes a shift in the standard treatment model from seek-and-destroy to target-and-control.

NEW YORK-The disadvantaged, once they have cancer, are then more likely to die from it, according to Prof. Harry Burns. "Poverty influences cancer in some quite unexpected ways," said Prof. Burns, director of public health, Greater Glasgow Health Board, Glasgow, Scotland. "The politicians, and all of us as voters, have a responsibility to think about this."

MELVILLE, New York-ONI is pleased to announce the creation of an Editorial Advisory Board for Oncology Nursing, to work with Sharon Krumm, PhD, RN, the Editor of Oncology Nursing, and staff to report research by oncology nurses and issues of special interest to oncology nurses. The first two appointees to the board are Catherine (Cathy) Coleman, RN, OCN, and Mary McCabe, BSN, MA.

PHILADELPHIA-Salvage therapy with the radiolabeled monoclonal antibody tositumomab (Bexxar) produced durable complete remissions in patients with multiply relapsed or refractory non-Hodgkin’s lymphoma (NHL) or transformed indolent lymphoma when used as second-line therapy, and first-line tositumomab produced 5-year progression-free survival of 58.9% in patients with advanced follicular lymphoma.

NEW ORLEANS-Template-based interstitial brachytherapy is an effective method for treating breast cancer, according to a study presented at the 44th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (abstract 147). The study is one of the first to use a template to position interstitial implants in its entire study population as part of its protocol.

NIAGARA-ON-THE-LAKE, Ontario, Canada-Survivors of childhood cancer generally enjoy good quality of life (QOL) as adults, according to two reports presented at the 7th International Conference for Long-Term Complications of Treatment of Children and Adolescents for Cancer, hosted by Roswell Park Cancer Institute.