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VANCOUVER, BC-Drug dependence is not physical dependence alone, nor is it the same as drug tolerance. "Drug dependence is primarily psychological dependence, or compulsive use of drugs for their mood-altering effects and continued use despite harm," David E. Joranson, MSSW, said at the WHO workshop on cancer pain.

ATLANTA, Ga-A group of mainly low-income African-American cancer patients had no difficulty completing a multidimensional pain measure, and among the unidimensional measures tested, preferred a faces scale, Deborah B. McGuire, PhD, RN, told Oncology News International at her poster presentation at the 8th World Congress on Pain

BETHESDA, Md-Two components of the National Institutes of Health will spend about $70 million over 5 years to fund Transdisciplinary Tobacco Use Research Centers at seven universities. The first year’s grants from the National Cancer Institute and the National Institute on Drug Abuse (NIDA) will total $14.5 million. In addition, the Robert Wood Johnson Foundation has committed another $14 million over the 5 years.

WASHINGTON-The latest effort to establish whether exposure to radiation during nuclear weapons tests caused leukemia in some military personnel has left the issue largely unresolved. The study by the Institute of Medicine (IOM) found a 14% increase in leukemia deaths among test participants, compared with a control group, but the increase was not significant. The increase was significant, however, for soldiers exposed to land-based testing.

WASHINGTON-A federal appeals court has granted expeditious status to an appeal seeking to overturn a US District Court decision that found parts of the Food and Drug Administration Modernization Act (FDAMA) unconstitutional. The district court ruling restricted the FDA’s powers to regulate the distribution by pharmaceutical companies to physicians of materials regarding off-label uses of drugs. [See Oncology News International, Oct. 1999, page 1.] The US Court of Appeals for the District of Columbia will hear oral arguments in the case on Jan. 4, 2000.

SAN FRANCISCO-Long-term estimates of survival utilizing data on 4,500 patients suggest that some people with HIV taking HAART (highly active antiviral therapy) may have a near-normal life expectancy. In a session on HIV at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), A.C. Justice, MD, of the Veterans Administration Pittsburgh Healthcare System, presented 2 years of recent data estimating long-term or immediate survival in the post-HAART era.

Physician groups are apt to seize on two aspects of the Clintonmedical records privacy proposal, which came out at the end of October and is expected to be finalized in February. The proposal

BUFFALO, NY-Cancer encompasses more than 100 different diseases and is caused by a series of molecular changes affecting cellular function. “We will find the solution to cancer at the molecular level. There are common patterns in tumor formation and certain keys that are associated with those patterns,” said Carlo Croce, MD, director of the Kimmel Cancer Center, and professor of microbiology and immunology, Thomas Jefferson University, Philadelphia.

The article by Drs. Labriola and Livingston is the first written collaboration of which I am aware between a doctor of naturopathic medicine and a professor of medicine at a major state university. The authors present a thorough review of the available information on interactions between dietary antioxidants, both natural and supplements, and chemotherapy.

NEW YORK-The 24-year-old patient recuperating from a bone marrow transplant in a hospital room at Memorial Sloan-Kettering Cancer Center was depressed and not communicating. The staff thought Lucanne Magill, the hospital music therapist, could help.

DENTON, Tex-Music has long been used, albeit unscientifically, to relax patients in an effort to relieve pain. Now, a researcher from the University of North Texas College of Music is attempting an approach to music therapy that involves vibration and appears to have a neurophysiologic mechanism of action.

SAN ANTONIO -Pretreatment with amifostine (Ethyol) reduced the incidence of both acute and chronic xero-stomia in patients undergoing head and neck radiotherapy, David M. Brizel, MD, reported at the 41st Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO).

BUFFALO, NY-Just by looking at the words cancer pain patients used to describe their pain, researchers were able to correctly predict in 66% of cases which patients had neuropathic pain, Dr. Thomas Sist, of the Roswell Park Cancer Institute, said in his poster presentation at the 8th World Congress on Pain.

EDMONTON, Alberta-Vigorous worldwide pain education efforts emphasizing undertreatment have resulted in a "very healthy increase" in the use of opioids around the world, including increases in dose and length of exposure, Eduardo Bruera, MD, of the University of Alberta and Edmonton General Hospital, said at a plenary session of the 8th World Congress on Pain.

PHOENIX, Arizona-Drugs that inhibit cyclooxygenase-2 (COX-2) are the hottest thing in arthritis care this year and may have a role to play in combating colorectal cancer, according to a study presented at the American College of Gastroenterology 64th Annual Scientific Meeting.

VANCOUVER, BC-The US Agency for Health Care Policy and Research (AHCPR) cancer pain practice guidelines, like the World Health Organization (WHO) 3-step ladder, emphasize a hierarchical pain management strategy, Richard Payne, MD, said at a symposium held in conjunction with the 8th World Congress on Pain of the International Association for the Study of Pain (IASP).

DULUTH, Minn-Effective strategies to improve cancer pain management in the community may be elusive, but researchers from the Minnesota Cancer Pain Project, led by Thomas E. Elliott, MD, believe they are on the right track with an intervention program that combines education of community opinion leaders with community outreach programs.

ST. LOUIS--When tramadol (Ultram) received FDA approval last year for use in moderate to moderately severe pain, its abuse potential was felt to be low (1.5 cases of abuse per 100,000 patients in the European experience).

BETHESDA, Md-Researchers at five institutions have received the first contracts awarded by a new National Cancer Institute program intended to develop novel “one-stop” technologies capable of both detecting and destroying tumor cells. The five contracts, each of which is for 3 years, totaled nearly $11.3 million.

VIENNA, Austria-Cancer pain patients with chronic renal failure are more likely than others to need changes in their morphine regimen, reported M. Escher, MD, of the Multidisciplinary Pain Center, University Hospital, Geneva, Switzerland. This retrospective study, reported at the 9th World Congress on Pain, reviewed medical records of 110 cancer patients who had been referred for a pain consultation and had been prescribed morphine.

Results of a study conducted by the American Society of Plastic and Reconstructive Surgeons (ASPRS) showed that 84% of women who have had their breast implants removed have replaced them with new implants. In 1998, 32,262 women with breast augmentation had their breast implants removed, and 27,320 of them opted for new implants.

SHEFFIELD, UK-What should the research question be when investigating a new approach to cancer pain? The most obvious answer is, Does it relieve pain? But David Brooks, MB, of the University of Sheffield, argues that this is not enough. Researchers must also ask about side effects, quality of life, and patient preference.

Although patients with cancer pain reported lower levels of current pain than did patients with benign or treatmentrelated pain, their pain anxiety levels were higher, Mikki Miner, RN, MS, said in a poster presentation at the 8th World Congress on Pain.

VANCOUVER, BC-More than 4,000 pain experts from all over the world attended the International Association for the Study of Pain (IASP) 8th World Congress on Pain, at the Vancouver Trade and Convention Centre.

VIENNA, Austria-Daily doses of controlled-release oral oxycodone (OxyContin, Oxygesic) exceeding 80 mg are as safe as lower doses when therapy is individualized, researchers from Purdue Pharma L.P. reported at the 9th World Congress on Pain.

VANCOUVER, BC-The use of pharmacoeconomics in cancer pain management is not about "decreasing the drug budget," but rather about evaluating the cost and outcomes of drug therapy, Stephen L. Huber, MS, RPh, said at a symposium held in conjunction with the 8th World Congress on Pain.

HOUSTON-Unscheduled hospital admissions for treatment of pain represent a significant cost-$4.7 million annually in a study from The University of Texas M.D. Anderson Cancer Center.

GLASGOW-Pain specialists continually stress the message that clinicians should not fear prescribing adequate doses of opioids for pain patients, since such patients are not at risk of becoming "addicted."

The Federal Trade Commission(FTC) released a consumer alert regarding home-use test kits for the human immunodeficiency virus (HIV). According to the FTC, some of the kits being marketed and sold on the Internet are giving users false information about their HIV status.

BETHESDA, Md-Nearly $8 million in grants will help 17 organizations establish 18 Biomarkers Developmental Laboratories, part of the National Cancer Institute’s new Early Detection Research Network. The laboratories are charged with identifying, characterizing, and refining techniques for finding molecular, genetic, and biologic biomarkers.