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WASHINGTON-Last year, tens of thousands gathered on The Mall in front of the US Capitol and in scores of communities nationwide to urge the federal government to make cancer the number one medical research priority. On Sept. 25, a candlelight vigil in front of the Lincoln Memorial will mark the first anniversary of that event, known as The March.

NEW ORLEANS-For the majority of mammographically detected invasive carcinomas with a mean size of 11 mm, stereotactic biopsy obtained with larger gauge needles provides adequate material for establishing a host of prognostic factors, said Michael D. Lagios, MD, medical director of the Breast Cancer Consultation Service, St. Mary’s Medical Center, San Francisco.

BETHESDA, Md-Using new computer software to “mine” existing databases, National Cancer Institute (NCI) scientists have discovered 10,435 possible new variations in human genes. The so-called single nucleotide polymorphisms, or SNPs, must still be validated, but NCI said each of the variations met statistical confidence levels of 0.99%.

LUGANO, Switzerland-Although a decade’s worth of phase II studies in advanced large-cell lymphoma have suggested that new, multidrug regimens could nearly double both the complete response rate and the proportion of long-term survivors, appearances can be deceiving, Richard Fisher, MD, Coleman Professor of Oncology, Loyola University Medical Center, Maywood, Illinois, said at the VII International Conference on Malignant Lymphoma.

NEW YORK-Memorial Sloan-Kettering Cancer Center’s new Laurance S. Rockefeller Outpatient Pavilion provides advanced programs for outpatient cancer diagnosis and treatment in a calm and beautiful environment. “We believe this facility will serve as a national model for the delivery of outpatient cancer care in the new millennium,” said Paul A. Marks, MD, president and CEO.

ROCKVILLE, Md-The Agency for Health Care Policy Research (AHCPR) plans to spend up to $11 million to fund two or three research centers to conduct studies of the health care market and managed care. The aim is to help policy makers understand, monitor, and anticipate how changes in the nation’s market-driven health care system affect costs, access to services, and quality of care. Interested researchers have until Sept. 2 , 1999, to submit letters of intent.

ORLANDO-“Nonsteroidal anti-inflammatory drugs (NSAIDs) confer protection against the common GI cancers, not only against colon and rectal cancer, which we’ve known about, but also in the esophagus and stomach, where the protection was at least as strong,” Michael Langman, MD, said at the Digestive Disease Week meeting.

WASHINGTON-Amid the artworks and antiques of the Diplomatic Rooms of the US State Department, the General Motors Cancer Research Foundation presented its awards to four scientists for their work related to cancer.

The City of Hope National Medical Center and Beckman Research Institute received the largest individual gift in the cancer center’s 86-year history from Irwin Helford, chairman of Viking Office Products and vice chairman of Office Depot. The

ORLANDO-A French study is “the first to quantify the frequency of anal cancer in HIV patients,” Iradj Sobhani, MD, said at the Digestive Disease Week meeting. “Anal carcinoma is rare in the general population, but relatively common in HIV-positive patients,” said Dr. Sobhani, of the Gastroenterology Service, Hopital Bichat, Paris.

WASHINGTON-An extensive review of the medical literature finds that women with silicone breast implants are no more likely to develop cancer and several other major ailments than women in the general population. The new report by the Institute of Medicine (IOM) concludes, however, that implants commonly lead to often-painful complications that may require surgery or other treatment.

PHILADELPHIA-Intranasal delivery of an adenoviral vector containing the murine interleukin-12 (IL-12) gene has been shown to inhibit osteosarcoma lung metastases in mice. IL-12 is a molecule that activates the immune system and has recently been shown to have antiangiogenic activity. “Our hypothesis is that IL-12 interfered with tumor angiogenesis,” Laura L. Worth, MD, PhD, said at the annual meeting of the American Association for Cancer Research.

NEW YORK- The law “need not be a barrier to good decisions at the end of life,” Carl H. Coleman, JD, executive director of the New York State Task Force on Life and the Law, said at a panel discussion on legal issues and end of life care sponsored by the Association of the Bar of the City of New York.

LUGANO, Switzerland-The impact of radiotherapy on disease control and toxicity in patients with advanced Hodgkin’s disease remains controversial. In fact, a 1998 meta-analysis suggested that combined-modality therapy results in worse long-term survival than does chemotherapy alone.

LUGANO, Switzerland-ChlVPP/EVA hybrid chemotherapy proved more effective than both MVPP and VAPEC-B as first-line treatment for advanced Hodgkin’s disease (HD) in two collaborative studies, Dr. John A. Radford, of Christie Hospital, Manchester, UK, reported at the VII International Conference on Malignant Lymphoma. The hybrid regimen consists of chlorambucil, vinblastine, procarbazine, and prednisone plus etoposide, vincristine, and doxorubicin (Adriamycin).

Peaceful Dying is a work of considerable effort and organization. Dr. Tobin has painstakingly analyzed his experience as a physician caring for patients with terminal illness and compiled a step-by-step guide to help both patients and their families

ROCKVILLE, Md-Doxil (doxorubicin HCl liposome injection, ALZA Corporation) has won accelerated FDA approval of its supplemental New Drug Application for the treatment of metastatic ovarian cancer refractory to both paclitaxel (Taxol)- and platinum-based chemotherapy regimens. Accelerated approval requires the company to conduct additional research to demonstrate that the drug is associated with clinical benefit. Doxil, a liposomal formulation of doxorubicin, is currently approved for use in AIDS-related Kaposi’s sarcoma.

ATLANTA-Mouthwash containing a modified virus that kills cells lacking p53 (a common deletion in many cancerous and precancerous lesions) may prevent development of invasive squamous cell head and neck cancers in smokers, researchers reported at the annual meeting of the American Society of Clinical Oncology.

RESEARCH TRIANGLE PARK, NC-After 6 years of research and 2 years of review, the National Institute of Environmental Health Sciences reported to Congress that the evidence that low-frequency electromagnetic fields (EMFs) can cause cancer and other human diseases is weak, but added that EMF exposure “cannot be recognized as entirely safe.”

NEW YORK-The Gillette Company has launched an initiative called The Gillette Women’s Cancer Connection to provide emotional support to cancer patients and their families. The program is specifically targeted at women with breast or gynecologic cancer.

CHICAGO-The new Children’s Oncology Group, which will include and replace four major pediatric cancer research groups, is expected to be up and running soon after the end of the year. The new cooperative group will include most researchers working on pediatric cancers and will initially comprise those currently associated with the Pediatric Oncology Group (POG), Children’s Cancer Group (CCG), National Wilms’ Tumor Study Group, and Intergroup Rhabdomyosarcoma Study Group.

NEW ORLEANS-Brachytherapy as the sole method of radiation treatment for patients undergoing breast-conserving therapy provides excellent local control, a cosmetic outcome comparable to external beam radiation therapy, and a low complication rate, according to several speakers at the American Society of Breast Disease meeting.

ORLANDO-Persons genetically at risk for colon cancer appear enthusiastic about participating in prevention trials, but researchers at Johns Hopkins had to recruit a large number of potential participants over a span of 2 years to find 41 people who qualified for their study and were willing to enroll, Linda Hylind, RN, said at Digestive Disease Week.

The most frequent pattern of pain related to cancer and cancer treatment consists of continuous pain punctuated by episodes of worsening pain. The cancer pain guidelines developed by the Agency for Health Care Policy and Research (AHCPR)

The malignant lymphomas are among the most responsive of neoplastic disorders. Objective tumor shrinkage has been seen after therapy with virtually all classes of chemotherapeutic agents, including alkylating agents, antimetabolites, vinca alkaloids,

Recombinant interferon-alfa (Intron A, Roferon-A) has been under investigation as a therapeutic agent for non-Hodgkin’s lymphoma (NHL) for 25 years. It has antitumor efficacy in a number of histologic subtypes but has not

Drs. Haase-Statz and Smalley review the role of interferon-alfa (Intron A, Roferon-A) in the treatment of lymphomas. As they point out in the introduction to their article, lymphoma is a very heterogeneous disease with more than 10 different entities and

Predicting the survival of terminal cancer patients is a difficult task. To better understand this difficulty, we divide prognostication into two distinct elements: foreseeing and foretelling. Foreseeing is a physician’s silent cognitive

NEW YORK-Clinical trials of the experimental oral agent exisulind (Prevatac) are underway for chemopre-vention of a variety of cancers, according to a report at Current Concepts in Cancer Therapy II, a scientific symposium sponsored by Long Ridge Associates.

NEW YORK-Two mornings a week, women who have had mastectomies or lumpectomies dip into the blue and white tiled pool at The Sol Goldman Young Men and Women’s Hebrew Association in Manhattan to laugh and splash, to reduce postoperative complications, and to feel alive and accepted. Beth Israel Medical Center and St. Luke’s-Roosevelt Hospital Center offer the Renewal Pool Program free to any woman who has had breast cancer surgery.