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BALTIMORE--Guilford Pharmaceuticals Inc.'s Gliadel biodegradable polymer implants significantly increased survival in a study of 32 patients with malignant glioma undergoing initial surgery. Gliadel wafers or placebo were inserted into the surgical cavity created when the brain tumor was removed, followed 3 weeks later by standard radiation therapy.

In this column, Dr. Alan Nelson, past president of the American Medical Association, has provided a set of goals for oncologic treatment under managed care contracts that can be embraced by all oncologists--choice, broad scope of practice, and communication. But the real message to oncologists is: Work together with internal medicine and primary care physicians to build a system that provides quality care of which everyone can be proud. Such cooperation is needed to help convert these treatment goals into workable contracts with primary care groups, HMOs, and/or insurers.

PHILADELPHIA--New court decisions are putting a damper on the insurance industry's attempts to deny coverage of experimental treatments by writing specific exclusions into their policies. These exclusions most often concern high-dose chemotherapy with autologous bone marrow transplantation (HDC/ABMT), said Karen L. Illuzzi Gallinari, a partner in the New York-based firm of Anderson Kill Olick & Oshinsky.

ROCKVILLE, Md--The Food and Drug Administration has approved a new indication for Roche Laboratories' Roferon-A (interferon alfa-2A recombinant). The agent, previously approved for use in treating hairy cell leukemia and AIDS-related Kaposi's sarcoma, is now also indicated for the treatment of chronic phase, Philadelphia chromosome positive chronic myelogenous leukemia (CML).

PARIS--Nearly 90% of patients with resected Dukes B and C colorectal carcinoma were still alive 3 years after active specific immunization with a new autologous tumor vaccine, researchers from the German Cancer Research Center, Heidelberg, and the University Hospital, Mannheim, Germany, have found.

HOUSTON--The University of Texas-Houston Health Science Center has been selected by the National Institutes of Health to be home to one of eight specialty centers that will conduct research into the effectiveness of alternative medicines used in cancer treatment.

WASHINGTON--Because of frequent inquiries from people needing references to answer those skeptics who question the link between HIV and AIDS, NIAID Director Anthony Fauci asked the Institute to put together a pamphlet explaining it all.

SAN ANTONIO--Physicians who treat HIV-infected patients may need to brace for patient inquiries in light of evidence that low-dose inter-leukin-2 (IL-2, Proleukin) may boost immune function following remission-inducing chemotherapy for AIDS-related malignancies.

NEW HAVEN, Conn--Vincent T. DeVita, Jr., MD, director of the Yale Cancer Center, has been honored with the 1995 Durham City of Medicine Award.

Forty years of research have had a tremendous impact on the treatmentof leukemia in both children and adult's, according to a panel

WASHINGTON--The Agency for Health Care Policy and Research (AHCPR) has awarded 10 research grants to study changes that are reshaping America's health-care system (see list below). The grants total $1.4 million for the first year; most of the projects will be completed in 2 years or less.

WASHINGTON--The Center for the Advancement of Health is working on a 3-year cancer initiative whose purpose is to increase support for psycho-social and biobehavioral research and services for cancer patients, said executive director Jessie Gruman, PhD. The Center was founded in 1992 by the John D. and Catherine T. MacArthur Foundation and the Nathan Cummings Foundation.

BETHESDA, Md--The lifetime risk of developing cancer for the US population is 44.8% for men and 39.3% for women, according to an analysis of incidence rates from the National Cancer Institute's SEER (Surveillance Epidemiology and End Results) program for 1973 to 1991.

MIAMI BEACH--Richard Hoppe, MD, has been named president-elect of the American Society for Therapeutic Radiology and Oncology (ASTRO). Dr. Hoppe is chairman of the Department of Radiation Oncology at Stanford University School of Medicine. He will take office at the Society's annual meeting to be held in Los Angeles next October.

SEATTLE--Filtering donated blood to remove cytomegalovirus (CMV) proved effective in an NIH-funded study from the Fred Hutchinson Cancer Research Center.

On the Greek island of Kos in the southeast Aegean, there is a cypress covered hill where ancient springs flow and herbs grow in abundance. People searching for good health have been coming to this hill for 25 generations. Hippocrates was born on Kos, and the hill holds the ruins of the ancient healing place, the Asclepieion.

A new technique for enriching progenitor blood cells and purging tumor cells before reinfusing the progentitor cells into cancer patients offers significant advantages over bone marrow for transplantation, according to investigators at Stanford University.

BUENOS AIRES--The tanning salon industry has grown enormously in recent years, with as many as 2 million regular patrons in the United States, and 1 million people visiting daily, W. L. Morrison, MD, of Johns Hopkins University, said at the Sixth World Congress on Cancers of the Skin.

MIAMI BEACH--Pretreatment hemoglobin level has been shown to have an independent effect on local control and survival in patients with T1-T2 squamous cell carcinomas of the glottic larynx, Douglas A. Fein, MD, reported at the annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO). Based on this finding, it may be advisable to correct anemia in these patients before starting radiation therapy, he said.

As oncology professionals, what initially drew us into this field was some mix of the mystery and intrigue of cancer with the

A 50-year-old man with multiple hospitalizations for chemotherapy for recurrent germ-cell carcinoma was admitted for nadir fever. A psychiatric consultation was requested for evaluation of anxiety and depression.

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2)both cause AIDS. Following the licensure of combination HIV-l/HIV-2

This column focuses on an area that is critical to all medical oncologists: the pharmacoeconomic analysis. Why should you take note of this?

LUXEMBOURG-In an effort to beat the skyrocketing costs of high-dose chemotherapy and transplantation, physicians at the Scripps Clinic, La Jolla, Calif, have launched a total outpatient therapy program that attempts to eliminate expensive hospital admissions.

BUENOS AIRES-Ultraviolet (UV) radiation contributes to skin cancer induction not only by transforming normal cells to cancer cells but also by impairing the host immune response to skin cancer, said Daniel Yarosh, PhD, president of Applied Genetics, Inc., Freeport, NY.

MONTREAL-The rising worldwide incidence of microbial resistance stems from a wide variety of causes and does not reflect a single global trend or etiology, Prof. Dr. Bernd Wiedemann, University of Bonn, Germany, said at a plenary session of the 19th International Congress of Chemotherapy.

LUXEMBOURG-Outpatient oral antibiotic therapy can be as effective and safe as outpatient parenteral therapy in the treatment of febrile neutropenia, according to the latest trial results from M.D. Anderson Cancer Center's Ambulatory and Supportive Care Oncology Research Program (ASCORP).

BUFFALO, NY-While a combination of pleurectomy and intracavitary photodynamic therapy marginally improves survival rates for some patients with malignant pleural mesothelioma, "there exists no compelling evidence that treatment of any kind is superior to no treatment," reported Hiroshi Takita, MD, DSc, chief of the Department of Thoracic Surgery, Roswell Park Cancer Institute.

Most physicians are so poor at communicating medical information to their patients that up to half of all patients leave their

SAN FRANCISCO-Clarithromy-cin (Biaxin), a newer generation macro-lide, has been shown to have a definite favorable effect on survival when given prophylactically to patients with advanced AIDS, Mark Pierce, MD, reported at the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy.