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Opinion|Videos|January 12, 2026

Antibody Drug Conjugates in Hormone Receptor Positive Disease – ASCENT-07 and Beyond

Author(s)Heather McArthur, MD, MPH, Sarah Sammons, MD, Ruta Rao, MD

Panelists discuss how results from antibody-drug conjugate trials, including those that fail primary endpoints, provide critical insights for refining sequencing strategies in hormone receptor–positive disease.

Episodes in this series

5 experts are featured in this series

EP. 1 Introduction and Genomic Testing in Advanced Breast Cancer

5 experts are featured in this series

EP. 2 Sequencing Targeted Therapies and Approaches for Genomic Versus Non-Genomic Cases

5 experts are featured in this series

EP. 3 Guideline Perspectives and the Shift Toward Earlier ADC Integration

5 experts are featured in this series

EP. 4 EMBER-3 and Progress in ESR1-Mutant Disease

5 experts are featured in this series

EP. 5 Post-CDK4/6 Endocrine Strategies and the evERA Trial

5 experts are featured in this series

EP. 6 Antibody Drug Conjugates in Hormone Receptor Positive Disease – ASCENT-07 and Beyond

5 experts are featured in this series

EP. 7 Optimizing HER2-Positive Disease Management: Neoadjuvant, Adjuvant, and Maintenance Advances

5 experts are featured in this series

EP. 8 High-Risk Populations, Patient Selection, and Advancements in Maintenance Therapy – Insights from Her2Climb05

5 experts are featured in this series

EP. 9 Toxicity Management, Monitoring, and Quality-of-Life Concerns

5 experts are featured in this series

EP. 10 Panel Reflections and Future Directions in Breast Cancer Care

In this section, Dr. Traina and the panel review first-line ADCs, specifically the ASCENT-07 trial investigating sacituzumab govitecan versus standard chemotherapy in metastatic hormone receptor-positive breast cancer. The results did not meet prespecified efficacy endpoints for progression-free survival, but insightful subgroup and secondary analysis provide value, enhancing understanding of ADC sequencing. Panelists discuss the importance of target selection (HER2 vs. Trop-2) in ADC efficacy, highlight differing responses in hormone receptor vs. triple negative disease, and emphasize how real-world drug access post-progression influences trial data interpretation. Lessons from negative trials are recognized as equally critical as positive data, providing guardrails for future therapy sequencing.

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