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Opinion|Videos|January 19, 2026

Optimizing HER2-Positive Disease Management: Neoadjuvant, Adjuvant, and Maintenance Advances

Author(s)Heather McArthur, MD, MPH, Sarah Sammons, MD, Ruta Rao, MD

Panelists discuss how emerging neoadjuvant and adjuvant data in HER2-positive breast cancer are challenging traditional standards and supporting earlier use of highly effective agents.

Episodes in this series

5 experts are featured in this series

EP. 1 Introduction and Genomic Testing in Advanced Breast Cancer

5 experts are featured in this series

EP. 2 Sequencing Targeted Therapies and Approaches for Genomic Versus Non-Genomic Cases

5 experts are featured in this series

EP. 3 Guideline Perspectives and the Shift Toward Earlier ADC Integration

5 experts are featured in this series

EP. 4 EMBER-3 and Progress in ESR1-Mutant Disease

5 experts are featured in this series

EP. 5 Post-CDK4/6 Endocrine Strategies and the evERA Trial

5 experts are featured in this series

EP. 6 Antibody Drug Conjugates in Hormone Receptor Positive Disease – ASCENT-07 and Beyond

5 experts are featured in this series

EP. 7 Optimizing HER2-Positive Disease Management: Neoadjuvant, Adjuvant, and Maintenance Advances

5 experts are featured in this series

EP. 8 High-Risk Populations, Patient Selection, and Advancements in Maintenance Therapy – Insights from Her2Climb05

Dr. Gradishar and the panel discuss significant advancements in HER2-positive breast cancer, focusing on Destiny-Breast05/11 trials investigating trastuzumab deruxtecan (TDXd) in neoadjuvant and adjuvant settings. They tackle ongoing debates regarding optimal timing for TDXd administration, nuances for patients with residual disease post-neoadjuvant therapy, and challenge traditional standards with new data showing improved invasive disease-free survival. The session addresses how earlier exposure to TDXd may inform later metastatic therapy options, the use of maintenance strategies, and the evolving role of endocrine therapy in HER2-positive patients.

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Joyce O’Shaughnessy, MD; Matthew P. Goetz, MD; Hope S. Rugo, MD, FASCO

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

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Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

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Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Cross-Disease Integration of Immunotherapy Innovations

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Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

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