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Opinion|Videos|January 12, 2026

Post-CDK4/6 Endocrine Strategies and the evERA Trial

Author(s)Heather McArthur, MD, MPH, Sarah Sammons, MD, Ruta Rao, MD

Panelists discuss how post-CDK4/6 endocrine strategies increasingly rely on molecular profiling to guide therapy selection and optimize benefit in resistant disease.

Episodes in this series

5 experts are featured in this series

EP. 1 Introduction and Genomic Testing in Advanced Breast Cancer

5 experts are featured in this series

EP. 2 Sequencing Targeted Therapies and Approaches for Genomic Versus Non-Genomic Cases

5 experts are featured in this series

EP. 3 Guideline Perspectives and the Shift Toward Earlier ADC Integration

5 experts are featured in this series

EP. 4 EMBER-3 and Progress in ESR1-Mutant Disease

5 experts are featured in this series

EP. 5 Post-CDK4/6 Endocrine Strategies and the evERA Trial

5 experts are featured in this series

EP. 6 Antibody Drug Conjugates in Hormone Receptor Positive Disease – ASCENT-07 and Beyond

Focus shifts to second-line strategies following CDK4/6 inhibitor progression. Dr. Sammons and the panel discuss the evERA trial results on the combination of giredestrant (a novel oral SERD) and everolimus versus standard-of-care are examined. Panelists dissect how efficacy appears particularly strong in the ESR1-mutant subgroup, but they also emphasize the necessity for molecular testing to guide therapy. They discuss the growing array of oral SERDs and their combination partner options, and reflect on the complexity added by these choices. The notion of tailoring therapies based on specific resistance mechanisms and prior duration of benefit forms a key takeaway, as does the caution needed when comparing trial outcomes across differing patient populations.

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Stay up to date on recent advances in the multidisciplinary approach to cancer.

Related Content

5 experts are featured in this series

Antibody Drug Conjugates in Hormone Receptor Positive Disease – ASCENT-07 and Beyond

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Academic–Community Coordination: Ensuring Safe Transitions of Care

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Case 1 Discussion: High-Risk MDS with TP53 Mutation

ByAmer Zeidan, MBBS ,Ralph V. Boccia, MD, FACP ,Salman Fazal, MD ,Susan Granato, CRNP ,Aditi Shastri, MBBS

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Evaluating Early Survival Signals and Treatment Timing in High-Risk Smoldering Multiple Myeloma

ByLarry Anderson, MD, PhD,Caitlin Costello, MD,Laahn Foster, MD

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