Breast Lesion in Patient With HIV

Breast Lesion in Patient With HIV

December 18, 2017

A 41-year-old woman with a past medical history notable for HIV underwent her first screening mammogram, which demonstrated a 1.5-cm irregular focal asymmetry in the left breast. What is your diagnosis?

A 41-year-old woman with a past medical history notable for HIV (diagnosed 3 years prior, currently being treated with emtricitabine/rilpivirine/tenofovir) underwent her first screening mammogram, which demonstrated a 1.5-cm irregular focal asymmetry in the left breast. There were no other significant masses, calcifications, or other notable findings in either breast.

An ultrasound was obtained, which re-demonstrated the suspicious lesion, measuring 1.4 cm × 1.7 cm × 1.2 cm. A biopsy was obtained. Pathologic examination of the specimen revealed CD20-positive B cells, which were negative for CD5, CD10, and cyclin D1. Germinal centers were also observed in the tissue sample.

A staging PET/CT was obtained, which was unremarkable except for the known lesion in the left breast.

What is your diagnosis?