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Opinion|Videos|January 8, 2026

CAR T Outcomes in LBCL: US Flatiron EMR Real-World Findings

Author(s)Matthew A. Lunning, DO, Loretta J. Nastoupil, MD, Brian T. Hill, MD, PhD

Fact checked by: Justin Mancini

Panelists analyze real-world outcomes for patients receiving CAR T therapy in LBCL using US electronic medical record data from Flatiron Health. Discussion highlights differences and similarities in survival outcomes, safety events such as CRS and neurotoxicity, and healthcare resource utilization in outpatient settings for two key CAR T products. Faculty consider how these findings compare with clinical trial data and inform real-world treatment expectations.

Episodes in this series

7 experts are featured in this series.

EP. 1 TRANSFORM + Long-Term Follow-Up ASH 2025 Insights: Durability, Survival, and Safety Updates

7 experts are featured in this series.

EP. 2 ZUMA-7 Final Analysis: Key Efficacy and Safety Findings

7 experts are featured in this series.

EP. 3 Real-World Treatment Patterns in R/R LBCL: Insights from Flatiron Data Pre & Post 2L CAR T Approval

7 experts are featured in this series.

EP. 4 CAR T Outcomes in LBCL: US Flatiron EMR Real-World Findings

7 experts are featured in this series.

EP. 5 Navigating 2L Treatment Pathways in LBCL

7 experts are featured in this series.

EP. 6 Optimizing CAR T-Cell Access & Delivery in R/R LBCL

7 experts are featured in this series.

EP. 7 Clinical Scenario: Treatment Decisions for a 31-Year-Old w/ R/R LBCL

7 experts are featured in this series.

EP. 8 Clinical Scenario: Treatment Decisions for a 53-Year-Old w/ R/R LBCL

Panelists analyze real-world outcomes for patients receiving CAR T therapy in LBCL using US electronic medical record data from Flatiron Health. Discussion highlights differences and similarities in survival outcomes, safety events such as CRS and neurotoxicity, and healthcare resource utilization in outpatient settings for two key CAR T products. Faculty consider how these findings compare with clinical trial data and inform real-world treatment expectations.

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