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Opinion|Videos|January 15, 2026

Navigating 2L Treatment Pathways in LBCL

Author(s)Matthew A. Lunning, DO, Loretta J. Nastoupil, MD, Brian T. Hill, MD, PhD

Fact checked by: Justin Mancini

Panelists debate optimal second-line treatment strategies for patients with relapsed/refractory LBCL. The discussion explores decision factors such as patient fitness and lifestyle, disease biology, timing of relapse, and transplant eligibility when selecting between CAR T-cell therapy and transplant-based approaches. Faculty weigh evolving evidence alongside practical considerations influencing treatment sequencing.

Episodes in this series

7 experts are featured in this series.

EP. 1 TRANSFORM + Long-Term Follow-Up ASH 2025 Insights: Durability, Survival, and Safety Updates

7 experts are featured in this series.

EP. 2 ZUMA-7 Final Analysis: Key Efficacy and Safety Findings

7 experts are featured in this series.

EP. 3 Real-World Treatment Patterns in R/R LBCL: Insights from Flatiron Data Pre & Post 2L CAR T Approval

7 experts are featured in this series.

EP. 4 CAR T Outcomes in LBCL: US Flatiron EMR Real-World Findings

7 experts are featured in this series.

EP. 5 Navigating 2L Treatment Pathways in LBCL

7 experts are featured in this series.

EP. 6 Optimizing CAR T-Cell Access & Delivery in R/R LBCL

7 experts are featured in this series.

EP. 7 Clinical Scenario: Treatment Decisions for a 31-Year-Old w/ R/R LBCL

7 experts are featured in this series.

EP. 8 Clinical Scenario: Treatment Decisions for a 53-Year-Old w/ R/R LBCL

Panelists debate optimal second-line treatment strategies for patients with relapsed/refractory LBCL. The discussion explores decision factors such as patient fitness and lifestyle, disease biology, timing of relapse, and transplant eligibility when selecting between CAR T-cell therapy and transplant-based approaches. Faculty weigh evolving evidence alongside practical considerations influencing treatment sequencing.

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