Opinion|Videos|January 22, 2026

Clinical Scenario: Treatment Decisions for a 53-Year-Old w/ R/R LBCL

Author(s)Matthew A. Lunning, DO, Loretta J. Nastoupil, MD, Brian T. Hill, MD, PhD

Fact checked by: Justin Mancini

Panelists review a patient with relapsed LBCL presenting with symptomatic disease and logistical barriers to treatment access. The discussion highlights how proximity to treatment centers, work demands, and concerns about toxicity influence therapy selection. Faculty consider practical approaches to balancing efficacy, access, and quality-of-life considerations.

Episodes in this series

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EP. 1 TRANSFORM + Long-Term Follow-Up ASH 2025 Insights: Durability, Survival, and Safety Updates

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EP. 2 ZUMA-7 Final Analysis: Key Efficacy and Safety Findings

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EP. 3 Real-World Treatment Patterns in R/R LBCL: Insights from Flatiron Data Pre & Post 2L CAR T Approval

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EP. 4 CAR T Outcomes in LBCL: US Flatiron EMR Real-World Findings

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EP. 5 Navigating 2L Treatment Pathways in LBCL

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EP. 6 Optimizing CAR T-Cell Access & Delivery in R/R LBCL

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EP. 7 Clinical Scenario: Treatment Decisions for a 31-Year-Old w/ R/R LBCL

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EP. 8 Clinical Scenario: Treatment Decisions for a 53-Year-Old w/ R/R LBCL

Panelists review a patient with relapsed LBCL presenting with symptomatic disease and logistical barriers to treatment access. The discussion highlights how proximity to treatment centers, work demands, and concerns about toxicity influence therapy selection. Faculty consider practical approaches to balancing efficacy, access, and quality-of-life considerations.

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