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Opinion|Videos|January 22, 2026

Clinical Scenario: Treatment Decisions for a 53-Year-Old w/ R/R LBCL

Author(s)Matthew A. Lunning, DO, Loretta J. Nastoupil, MD, Brian T. Hill, MD, PhD

Fact checked by: Justin Mancini

Panelists review a patient with relapsed LBCL presenting with symptomatic disease and logistical barriers to treatment access. The discussion highlights how proximity to treatment centers, work demands, and concerns about toxicity influence therapy selection. Faculty consider practical approaches to balancing efficacy, access, and quality-of-life considerations.

Episodes in this series

7 experts are featured in this series.

EP. 1 TRANSFORM + Long-Term Follow-Up ASH 2025 Insights: Durability, Survival, and Safety Updates

7 experts are featured in this series.

EP. 2 ZUMA-7 Final Analysis: Key Efficacy and Safety Findings

7 experts are featured in this series.

EP. 3 Real-World Treatment Patterns in R/R LBCL: Insights from Flatiron Data Pre & Post 2L CAR T Approval

7 experts are featured in this series.

EP. 4 CAR T Outcomes in LBCL: US Flatiron EMR Real-World Findings

7 experts are featured in this series.

EP. 5 Navigating 2L Treatment Pathways in LBCL

7 experts are featured in this series.

EP. 6 Optimizing CAR T-Cell Access & Delivery in R/R LBCL

7 experts are featured in this series.

EP. 7 Clinical Scenario: Treatment Decisions for a 31-Year-Old w/ R/R LBCL

7 experts are featured in this series.

EP. 8 Clinical Scenario: Treatment Decisions for a 53-Year-Old w/ R/R LBCL

Panelists review a patient with relapsed LBCL presenting with symptomatic disease and logistical barriers to treatment access. The discussion highlights how proximity to treatment centers, work demands, and concerns about toxicity influence therapy selection. Faculty consider practical approaches to balancing efficacy, access, and quality-of-life considerations.

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