Opinion|Videos|July 1, 2024
Clinical Implications of MajesTEC-1
Author(s)Amrita Y. Krishnan, MD, Binod Dhakal, MD, MS
Amrita Y. Krishnan, MD, and Binod Dhakal, MD, discuss the clinical implications of data from MajesTEC-1 and provide key takeaways on the evolving relapsed/refractory multiple myeloma treatment landscape.
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Video content above is prompted by the following questions:
- Based on the long-term efficacy and safety data presented for teclistamab in the MajesTEC-1 trial, what are your key takeaways or clinical implications for the use of this agent in patients with relapsed/refractory multiple myeloma (R/R MM)?
- Despite the promising results with teclistamab, what potential unmet needs or areas for further research and development remain in the treatment of R/R MM?
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Related to this article
In a phase 2 trial, CD38-targeted immune-PET detected active multiple myeloma in some patients with no signs of disease on standard fluorodeoxyglucose PET/CT.
“If it is successful, you should be able to access this combination wherever you are,” said Natalie S. Callander, MD, of the UW Carbone Cancer Center.
Data from the phase 3 CERVINO trial support the application for etentamig as a treatment for adults with relapsed or refractory multiple myeloma.
The MagnetisMM-32 trial may support elranatamab as an important option for those whose disease has progressed following anti-CD38 therapy and lenalidomide.
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