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Opinion|Videos|April 1, 2026

Debate Round 1: Should CAR-T Be Given Inpatient or Outpatient?

Author(s)Megan Melody, MD, Matthew Cortese, MD, MPH, Marco Davila, MD, PhD

Panelists engage in a structured debate on whether CAR T-cell therapy for aggressive large B-cell lymphoma should be administered in the inpatient or outpatient setting. Team NYC argues for inpatient treatment in higher-risk or socially complex cases, citing logistical barriers, caregiver limitations, and the need to manage serious toxicities such as CRS and ICANS. Team Roswell counters that outpatient programs can safely expand access, reduce hospital-related complications, and improve patient acceptance of CAR T, prompting a broader discussion on evolving safety data, real-world logistics, and changing regulatory requirements.

Episodes in this series

7 experts are featured in this series.

EP. 1 Treatment Selection in Biologically Aggressive DLBCL

7 experts are featured in this series.

EP. 2 Real-World CAR-T Comparisons: Axi-cel vs Liso-cel in 2L LBCL

7 experts are featured in this series.

EP. 3 US Registry: Comparing Second-Line CAR-T Products in LBCL

7 experts are featured in this series.

EP. 4 Debate Round 1: Should CAR-T Be Given Inpatient or Outpatient?

Panelists engage in a structured debate on whether CAR T-cell therapy for aggressive large B-cell lymphoma should be administered in the inpatient or outpatient setting. Team NYC argues for inpatient treatment in higher-risk or socially complex cases, citing logistical barriers, caregiver limitations, and the need to manage serious toxicities such as CRS and ICANS. Team Roswell counters that outpatient programs can safely expand access, reduce hospital-related complications, and improve patient acceptance of CAR T, prompting a broader discussion on evolving safety data, real-world logistics, and changing regulatory requirements.

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