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Opinion|Videos|April 15, 2026

Debate Round 3: CAR-T vs Bispecifics in Relapsed LBCL – “Cure” vs Access

Author(s)Megan Melody, MD, Matthew Cortese, MD, MPH, Marco Davila, MD, PhD

The teams debate whether CAR-T or bispecific antibodies should be prioritized as the treatment paradigm evolves in relapsed large B-cell lymphoma, with Team NYC centering the argument on “cure” and the curative-intent potential/plateau of CAR-T outcomes. Team Roswell agrees cure is the goal but argues that real-world access barriers and “off-the-shelf” availability make bispecifics, and especially emerging combination strategies, crucial for patients who cannot reliably reach or complete CAR-T. The discussion highlights a key tradeoff: CAR T as a one-time, time-limited intervention vs bispecifics requiring ongoing dosing and infrastructure, with durability, infection risk, and sequencing still actively evolving.

Episodes in this series

7 experts are featured in this series.

EP. 1 Treatment Selection in Biologically Aggressive DLBCL

7 experts are featured in this series.

EP. 2 Real-World CAR-T Comparisons: Axi-cel vs Liso-cel in 2L LBCL

7 experts are featured in this series.

EP. 3 US Registry: Comparing Second-Line CAR-T Products in LBCL

7 experts are featured in this series.

EP. 4 Debate Round 1: Should CAR-T Be Given Inpatient or Outpatient?

7 experts are featured in this series.

EP. 5 Debate Round 2: Choosing a 2L CAR-T Product

7 experts are featured in this series.

EP. 6 Debate Round 3: CAR-T vs Bispecifics in Relapsed LBCL – “Cure” vs Access

The teams debate whether CAR-T or bispecific antibodies should be prioritized as the treatment paradigm evolves in relapsed large B-cell lymphoma, with Team NYC centering the argument on “cure” and the curative-intent potential/plateau of CAR-T outcomes. Team Roswell agrees cure is the goal but argues that real-world access barriers and “off-the-shelf” availability make bispecifics, and especially emerging combination strategies, crucial for patients who cannot reliably reach or complete CAR-T. The discussion highlights a key tradeoff: CAR T as a one-time, time-limited intervention vs bispecifics requiring ongoing dosing and infrastructure, with durability, infection risk, and sequencing still actively evolving.

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